BDP1 Antibody (C-2): sc-166710

BDP1 Antibody (C-2) is a mouse monoclonal IgG1 antibody that detects BDP1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). BDP1, or brain-derived phosphatase 1, is a crucial member of the PEST protein tyrosine phosphatase family, playing a significant role in the regulation of protein tyrosine phosphorylation, which is essential for various cellular processes including growth, migration, and differentiation. The unique structure of BDP1, characterized by its PEST sequence, contributes to stability and activity, allowing BDP1 to effectively dephosphorylate specific tyrosine kinases such as src and epidermal growth factor receptor (EGFR), which are often overexpressed in tumor tissues. This structural feature not only enhances enzymatic function but also underscores importance in cellular signaling pathways, making BDP1 a valuable target for research in cancer biology and therapeutic development. Anti-BDP1 antibody (C-2) is ideal for studies aimed at understanding the intricate balance of phosphorylation and dephosphorylation in cellular signaling, particularly in the context of tumorigenesis.

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BDP1 Antibody (C-2) References:

1. Essential roles of Bdp1, a subunit of RNA polymerase III initiation factor TFIIIB, in transcription and tRNA processing.  |  Ishiguro, A., et al. 2002. Mol Cell Biol. 22: 3264-75. PMID: 11971960
2. The zinc finger protein ZNF297B interacts with BDP1, a subunit of TFIIIB.  |  Schoenen, F. and Wirth, B. 2006. Biol Chem. 387: 277-84. PMID: 16542149
3. A Region of Bdp1 Necessary for Transcription Initiation That Is Located within the RNA Polymerase III Active Site Cleft.  |  Hu, HL., et al. 2015. Mol Cell Biol. 35: 2831-40. PMID: 26055328
4. Molecular mechanisms of Bdp1 in TFIIIB assembly and RNA polymerase III transcription initiation.  |  Gouge, J., et al. 2017. Nat Commun. 8: 130. PMID: 28743884
5. Bdp1 interacts with SNAPc bound to a U6, but not U1, snRNA gene promoter element to establish a stable protein-DNA complex.  |  Verma, N., et al. 2018. FEBS Lett. 592: 2489-2498. PMID: 29932462
6. Somatic mutations of cancer-related genes PELP1 and BDP1 in colorectal cancers.  |  Son, HJ., et al. 2020. Pathol Res Pract. 216: 153107. PMID: 32853945
7. BDP1 Variants I1264M and V1347M Significantly Associated with Clinical Outcomes of Pediatric Neuroblastoma Patients Imply a New Prognostic Biomarker: A 121-Patient Cancer Genome Study.  |  Li, X., et al. 2021. Diagnostics (Basel). 11: PMID: 34943600
8. Comment on Li et al. BDP1 Variants I1264M and V1347M Significantly Associated with Clinical Outcomes of Pediatric Neuroblastoma Patients Imply a New Prognostic Biomarker: A 121-Patient Cancer Genome Study. Diagnostics 2021, 11, 2364.  |  Schramm, L. 2022. Diagnostics (Basel). 12: PMID: 35328161
9. BDP1 Alterations Correlate with Clinical Outcomes in Breast Cancer.  |  Cabarcas-Petroski, S. and Schramm, L. 2022. Cancers (Basel). 14: PMID: 35406430
10. BDP1 as a biomarker in serous ovarian cancer.  |  Cabarcas-Petroski, S., et al. 2023. Cancer Med. 12: 6401-6418. PMID: 36305848

The preferred BDP1 antibody is BDP1 Antibody (B-6): sc-515058.