Bcl10 Antibody (151): sc-56023

Bcl10 Antibody (151) is a mouse monoclonal IgG1 antibody that detects Bcl10 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Bcl10, also known as CIPER, c-CARMEN, and mE10, plays a crucial role in the regulation of apoptosis and immune responses, primarily through involvement in the NFκB signaling pathway. Bcl10 contains an N-terminal caspase recruitment domain (CARD), which is essential for function in activating NFκB via a NIK-dependent mechanism. This activation influences various cellular processes, including inflammation and cell survival. While Bcl10 promotes apoptosis through CARD-mediated oligomerization, Bcl10 has also been shown to facilitate the processing of caspase-9 into active dimer form, further underscoring importance in apoptotic signaling. Despite association with certain tumor types, Bcl10 is not frequently mutated in many human tumors and lymphomas, indicating that expression and functional integrity may be critical for maintaining normal cellular homeostasis. Anti-Bcl10 antibody (151) is an invaluable tool for researchers investigating the complex roles of Bcl10 in cellular signaling and disease mechanisms.

The preferred Bcl10 antibody is Bcl10 Antibody (331.3): sc-5273.