Bcl-xS/L Antibody (4H33): sc-70418
- Bcl-xS/L Antibody (4H33) is a mouse monoclonal IgG2a κ, cited in 4 publications, provided at 200 µg/ml
- raised against an N-terminal peptide (amino acids 3-14) common to human and mouse Bcl-xL and Bcl-xS
- recommended for detection of Bcl-xL and Bcl-xs of mouse, rat and human origin by WB, IP, IF and IHC(P)
- See Bcl-xL (H-5): sc-8392 for Bcl-xS/L antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for Bcl-xS/L Antibody (4H33) for WB and IHC(P) applications. These reagents are now offered in bundles with Bcl-xS/L Antibody (4H33) (see ordering information below).
Bcl-xS/L Antibody (4H33) is a mouse monoclonal IgG2a antibody that detects Bcl-xS/L in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Bcl-xS/L plays a crucial role in regulating apoptosis, acting as a pro-apoptotic member of the Bcl-2 family. Bcl-xS/L is primarily located in mitochondria, where Bcl-xS/L interacts with other Bcl-2 family members to modulate cell survival and death pathways. This localization allows Bcl-xS/L to directly influence mitochondrial membrane permeability, a key event in the apoptotic process. By promoting cytochrome c release from mitochondria, Bcl-xS/L facilitates caspase activation, which is essential for executing apoptosis. The balance between pro-apoptotic and anti-apoptotic signals, such as those mediated by Bcl-xS/L and counterparts like Bcl-2, is vital for maintaining cellular homeostasis and preventing uncontrolled cell proliferation, which can lead to cancer. Anti-Bcl-xS/L antibody (4H33) serves as an invaluable tool for researchers studying apoptosis and its implications in various diseases, including cancer and neurodegenerative disorders.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Bcl-xS/L Antibody (4H33) | sc-70418 | 200 µg/ml | $322.00 | |||
Bcl-xS/L Antibody (4H33): m-IgG Fc BP-HRP Bundle | sc-539276 | 200 µg Ab; 10 µg BP | $361.00 | |||
Bcl-xS/L Antibody (4H33): m-IgG2a BP-HRP Bundle | sc-546687 | 200 µg Ab; 10 µg BP | $361.00 |