Bcl-xS/L Antibody (4E19): sc-70417
- Bcl-xS/L Antibody (4E19) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- raised against an N-terminal peptide (amino acids 3-14) common to human and mouse Bcl-xL and Bcl-xS
- recommended for detection of Bcl-xL and Bcl-xs of mouse, rat and human origin by WB, IP, IF and IHC(P)
- See Bcl-xL (H-5): sc-8392 for Bcl-xS/L antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for Bcl-xS/L Antibody (4E19) for WB and IHC(P) applications. This reagent is now offered in a bundle with Bcl-xS/L Antibody (4E19) (see ordering information below).
Bcl-xS/L Antibody (4E19) is a mouse monoclonal IgG2a antibody that detects Bcl-xS/L in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Bcl-xS/L plays a crucial role in regulating apoptosis, acting as a pro-apoptotic member of the Bcl-2 family. Bcl-xS/L is primarily located in mitochondria, where anti-Bcl-xS/L antibody (4E19) can detect interactions with other Bcl-2 family members that modulate cell survival and death pathways. This localization allows Bcl-xS/L to directly influence mitochondrial membrane permeability, a key event in the apoptotic process. By promoting cytochrome c release from mitochondria, Bcl-xS/L facilitates caspase activation, which is essential for executing apoptosis. The balance between pro-apoptotic and anti-apoptotic signals, including those mediated by Bcl-xS/L and counterparts like Bcl-2, maintains cellular homeostasis and prevents uncontrolled cell proliferation that can lead to cancer. Bcl-xS/L monoclonal antibody (4E19) serves as a valuable tool for studying apoptosis and its implications in various diseases, including cancer and neurodegenerative disorders.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Bcl-xS/L Antibody (4E19) | sc-70417 | 200 µg/ml | $322.00 | |||
Bcl-xS/L Antibody (4E19): m-IgG Fc BP-HRP Bundle | sc-551950 | 200 µg Ab; 10 µg BP | $361.00 |