Bcl-xS/L Antibody (4E19): sc-70417

Bcl-xS/L Antibody (4E19) is a mouse monoclonal IgG2a antibody that detects Bcl-xS/L in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Bcl-xS/L plays a crucial role in regulating apoptosis, acting as a pro-apoptotic member of the Bcl-2 family. Bcl-xS/L is primarily located in mitochondria, where anti-Bcl-xS/L antibody (4E19) can detect interactions with other Bcl-2 family members that modulate cell survival and death pathways. This localization allows Bcl-xS/L to directly influence mitochondrial membrane permeability, a key event in the apoptotic process. By promoting cytochrome c release from mitochondria, Bcl-xS/L facilitates caspase activation, which is essential for executing apoptosis. The balance between pro-apoptotic and anti-apoptotic signals, including those mediated by Bcl-xS/L and counterparts like Bcl-2, maintains cellular homeostasis and prevents uncontrolled cell proliferation that can lead to cancer. Bcl-xS/L monoclonal antibody (4E19) serves as a valuable tool for studying apoptosis and its implications in various diseases, including cancer and neurodegenerative disorders.

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Bcl-xS/L Antibody (4E19) References:

1. The anti-apoptotic protein BCL2L1/Bcl-xL is neutralized by pro-apoptotic PMAIP1/Noxa in neuroblastoma, thereby determining bortezomib sensitivity independent of prosurvival MCL1 expression.  |  Hagenbuchner, J., et al. 2010. J Biol Chem. 285: 6904-12. PMID: 20051518
2. BCL2L1 has a functional role in colorectal cancer and its protein expression is associated with chromosome 20q gain.  |  Sillars-Hardebol, AH., et al. 2012. J Pathol. 226: 442-50. PMID: 22009326
3. Downregulation of miRNA-663b protects against hypoxia-induced injury in cardiomyocytes by targeting BCL2L1.  |  Yu, F., et al. 2020. Exp Ther Med. 19: 3581-3588. PMID: 32346421
4. BCL-xL/BCL2L1 is a critical anti-apoptotic protein that promotes the survival of differentiating pancreatic cells from human pluripotent stem cells.  |  Loo, LSW., et al. 2020. Cell Death Dis. 11: 378. PMID: 32424151
5. Defective functions of HNF1A variants on BCL2L1 transactivation and beta-cell growth.  |  Sujjitjoon, J., et al. 2020. Biochem Biophys Res Commun. 529: 826-833. PMID: 32684311
6. Dual inhibition of FGFR4 and BCL-xL inhibits multi-resistant ovarian cancer with BCL2L1 gain.  |  Guo, T., et al. 2021. Aging (Albany NY). 13: 19750-19759. PMID: 34351305
7. Dexmedetomidine attenuates propofol-induced apoptosis of neonatal hippocampal astrocytes by inhibiting the Bcl2l1 signalling pathway.  |  Sun, WC. and Pei, L. 2021. Eur J Neurosci. 54: 7775-7789. PMID: 34734676
8. Tilianin Reduces Apoptosis via the ERK/EGR1/BCL2L1 Pathway in Ischemia/Reperfusion-Induced Acute Kidney Injury Mice.  |  Liu, Z., et al. 2022. Front Pharmacol. 13: 862584. PMID: 35721209
9. Amsacrine downregulates BCL2L1 expression and triggers apoptosis in human chronic myeloid leukemia cells through the SIDT2/NOX4/ERK/HuR pathway.  |  Lee, YC., et al. 2023. Toxicol Appl Pharmacol. 474: 116625. PMID: 37451322
10. Dual inhibition of KIF11 and BCL2L1 induces apoptosis in lung adenocarcinoma cells.  |  Sakuma, Y., et al. 2023. Biochem Biophys Res Commun. 678: 84-89. PMID: 37619315

The preferred Bcl-x_L antibody is Bcl-x_L Antibody (H-5): sc-8392.