Bcl-w Antibody (2E4): sc-293236

Bcl-w Antibody (2E4) is a mouse monoclonal IgG2a kappa light chain antibody that detects Bcl-w protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-Bcl-w antibody (2E4) is available as a non-conjugated format. Bcl-w, also known as BCL2L2, plays a crucial role in regulating apoptosis, which is essential for maintaining cellular homeostasis and tissue integrity. Bcl-w belongs to the Bcl-2 family, which consists of both pro-apoptotic and anti-apoptotic members that work in concert to determine cell fate. Bcl-w specifically promotes cell survival, particularly in myeloid cells, and expression is tightly regulated in various tissues, highlighting importance in hematopoiesis and immune responses. Bcl-w is encoded by a gene located near the TCRa gene on chromosome 14 and exhibits high conservation between species, indicating fundamental biological significance. Notably, Bcl-w undergoes alternative splicing, resulting in two distinct transcripts: full-length Bcl-w, which encodes a 193 amino acid protein, and Bcl-w/rox, which encodes a longer protein of 333 amino acids. The "rox" variant shares significant sequence identity with the Drosophila rox2 protein, suggesting potential evolutionary links and functional implications. Bcl-w (2E4) antibody serves as an invaluable tool for researchers studying apoptosis and regulation in various biological contexts.

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Bcl-w Antibody (2E4) References:

1. Estrogen regulates Bcl-w and Bim expression: role in protection against beta-amyloid peptide-induced neuronal death.  |  Yao, M., et al. 2007. J Neurosci. 27: 1422-33. PMID: 17287517
2. Oxidative Modification of miR-184 Enables It to Target Bcl-xL and Bcl-w.  |  Wang, JX., et al. 2015. Mol Cell. 59: 50-61. PMID: 26028536
3. BCL-W makes only minor contributions to MYC-driven lymphoma development.  |  Diepstraten, ST., et al. 2023. Oncogene. 42: 2776-2781. PMID: 37567974
4. Effective Targeting of Melanoma Cells by Combination of Mcl-1 and Bcl-2/Bcl-xL/Bcl-w Inhibitors.  |  Peng, Z., et al. 2024. Int J Mol Sci. 25: PMID: 38542429
5. The bcl-2 gene family.  |  Craig, RW. 1995. Semin Cancer Biol. 6: 35-43. PMID: 7548840
6. Multiple Bcl-2 family members demonstrate selective dimerizations with Bax.  |  Sedlak, TW., et al. 1995. Proc Natl Acad Sci U S A. 92: 7834-8. PMID: 7644501
7. Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death.  |  Yang, E., et al. 1995. Cell. 80: 285-91. PMID: 7834748
8. Novel Drosophila melanogaster genes encoding RRM-type RNA-binding proteins identified by a degenerate PCR strategy.  |  Brand, SF., et al. 1995. Gene. 154: 187-92. PMID: 7890163
9. Cloning of human Bcl-2 homologue: inflammatory cytokines induce human A1 in cultured endothelial cells.  |  Karsan, A., et al. 1996. Blood. 87: 3089-96. PMID: 8605321
10. bcl-w, a novel member of the bcl-2 family, promotes cell survival.  |  Gibson, L., et al. 1996. Oncogene. 13: 665-75. PMID: 8761287
11. A novel Bcl-2/Bcl-X(L)/Bcl-w inhibitor ABT-737 as therapy in multiple myeloma.  |  Chauhan, D., et al. 2007. Oncogene. 26: 2374-80. PMID: 17016430
12. 'Seed' analysis of off-target siRNAs reveals an essential role of Mcl-1 in resistance to the small-molecule Bcl-2/Bcl-XL inhibitor ABT-737.  |  Lin, X., et al. 2007. Oncogene. 26: 3972-9. PMID: 17173063

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Bcl-w Antibody (2E4) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Bcl-w Antibody (2E4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Bcl-w Antibody (2E4) Specifications

Alternate Product Name: BCLW

Product Clone Name: 2E4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-193

Epitope Target: Bcl-w

Epitope Species: human

Product Reactivity/Detection: Bcl-w

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Bcl-w Antibody (2E4): N/A