Bcl-rambo Antibody (Rocky-2): sc-56020
- Bcl-rambo Antibody (Rocky-2) is a mouse monoclonal IgG1 provided at 50 µg/0.5 ml
- raised against amino acids 224-459 of Bcl-rambo of human origin
- recommended for detection of Bcl-rambo of human origin by WB, IP and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Bcl-rambo Antibody (Rocky-2). This work is in progress.
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Bcl-rambo Antibody (Rocky-2) is a mouse monoclonal IgG1 antibody that detects Bcl-rambo in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Bcl-rambo, a crucial member of the Bcl-2 family, plays a significant role in regulating apoptosis, a vital process for maintaining cellular homeostasis and eliminating damaged cells. Bcl-rambo is primarily localized to mitochondria, where anti-Bcl-rambo antibody (Rocky-2) can detect its pro-apoptotic effects. The mitochondrial location enables Bcl-rambo to interact directly with key components of the apoptotic machinery, facilitating cytochrome c release from mitochondria into the cytosol, which is a critical step in caspase activation and apoptosis execution. Notably, Bcl-rambo′s unique C-terminal region, containing two tandem repeats preceding the membrane anchor, distinguishes Bcl-rambo from other Bcl-2 family members and is integral to function. By promoting mitochondrial cytochrome c release and potentially activating caspase-3, Bcl-rambo serves as a pivotal regulator of apoptosis, making Bcl-rambo an important target for research in cancer and other diseases characterized by dysregulated cell death.
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Bcl-rambo Antibody (Rocky-2) References:
- Bcl-rambo, a novel Bcl-2 homologue that induces apoptosis via its unique C-terminal extension. | Kataoka, T., et al. 2001. J Biol Chem. 276: 19548-54. PMID: 11262395
- Bcl-rambo beta, a special splicing variant with an insertion of an Alu-like cassette, promotes etoposide- and Taxol-induced cell death. | Yi, P., et al. 2003. FEBS Lett. 534: 61-8. PMID: 12527362
- Effect of interaction of magnetic nanoparticles of Fe₃O₄ and artesunate on apoptosis of K562 cells. | Wang, Y., et al. 2011. Int J Nanomedicine. 6: 1185-92. PMID: 21822380
- Bcl-rambo induces apoptosis via interaction with the adenine nucleotide translocator. | Kim, JY., et al. 2012. FEBS Lett. 586: 3142-9. PMID: 22921587
- MNPs-Fe₃O₄mediates malignant Hematolpoectic cell apoptosis. | Li, YQ., et al. 2014. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 22: 1649-55. PMID: 25543491
- The Human Bcl-2 Family Member Bcl-rambo Localizes to Mitochondria and Induces Apoptosis and Morphological Aberrations in Drosophila. | Nakazawa, M., et al. 2016. PLoS One. 11: e0157823. PMID: 27348811
- Selective binding of mitophagy receptor protein Bcl-rambo to LC3/GABARAP family proteins. | Li, M., et al. 2020. Biochem Biophys Res Commun. 530: 292-300. PMID: 32828302
- Corrigendum to: The human Bcl-2 family member Bcl-rambo and voltage-dependent anion channels manifest a genetic interaction in Drosophila and cooperatively promote the activation of effector caspases in human cultured cells. | Matsubara, H., et al. 2021. Exp Cell Res. 405: 112711. PMID: 34217518
- PGAM5 interacts with Bcl-rambo and regulates apoptosis and mitophagy. | Hashino, T., et al. 2022. Exp Cell Res. 420: 113342. PMID: 36075447
- The BCL-2 family protein BCL-RAMBO interacts and cooperates with GRP75 to promote its apoptosis signaling pathway. | Xu, J., et al. 2023. Sci Rep. 13: 14041. PMID: 37640805
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Bcl-rambo Antibody (Rocky-2) | sc-56020 | 50 µg/0.5 ml | $322.00 |