Bcl-G Antibody (F-8): sc-393715

Bcl-G Antibody (F-8) is a mouse monoclonal IgG2a antibody that detects Bcl-G in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Bcl-G, also known as BCL2L14 or BCLG, is a 327 amino acid cytoplasmic protein that plays a crucial role in regulating apoptosis, a process essential for maintaining tissue homeostasis and protecting against diseases, including cancer. Bcl-G belongs to the Bcl-2 family, known for involvement in apoptotic signaling pathways. Bcl-G is expressed in three alternatively spliced isoforms: short, medium, and long, with the short isoform being testis-specific and localized to cytosolic organelles, while the long isoform is more widely distributed throughout the cytosol. The structural diversity of these isoforms allows for differential regulation of apoptotic processes in various tissues, highlighting Bcl-G′s importance in both normal physiological functions and potential tumor suppression mechanisms. Overexpression of Bcl-G has been shown to induce apoptosis, suggesting a critical role in cellular responses to stress and potential as a therapeutic target in cancer treatment. Anti-Bcl-G antibody (F-8) serves as an invaluable tool for researchers studying apoptosis and its implications in human health and disease.

The preferred Bcl-G antibody is Bcl-G Antibody (E-10): sc-398223.