Bcl-9 Antibody (2071C3a): sc-81199

Bcl-9 Antibody (2071C3a) is a mouse monoclonal IgG1 antibody that detects Bcl-9 in human samples through western blotting (WB) and immunoprecipitation (IP) applications. Bcl-9, also known as B-cell CLL/lymphoma 9 protein, is a crucial nuclear protein encoded by the human gene BCL9 and plays a significant role in the Wnt signaling pathway, which is essential for regulating various cell fates during animal development. The proper functioning of this pathway is vital, as disruptions can lead to oncogenesis in multiple human tissues. Bcl-9 interacts with β-catenin, a key effector of the canonical Wnt pathway, forming a nuclear complex that includes Bcl-9/Bcl-9L and other proteins, which collectively activate the transcription of several Wnt target genes such as FGF-20, WISP-1, Myc, and Glucagon. Understanding the interactions and functions of Bcl-9 is critical, as this knowledge not only highlights Bcl-9′s role in normal cellular processes but also underscores potential implications in cancer biology, making anti-Bcl-9 antibody (2071C3a) an invaluable tool for researchers investigating the intricacies of Wnt signaling and its impact on human health.