Bcl-2 Antibody (8C8): sc-65392
- Bcl-2 Antibody (8C8) is a mouse monoclonal IgG1 κ, cited in 22 publications, provided at 200 µg/ml
- raised against Bcl-2 of human origin
- recommended for detection of Bcl-2 of human origin by WB, IP and IHC(P)
- See Bcl-2 (C-2): sc-7382 for Bcl-2 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for Bcl-2 Antibody (8C8) for WB and IHC(P) applications. This reagent is now offered in a bundle with Bcl-2 Antibody (8C8) (see ordering information below).
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SEE ALSO...
Bcl-2 Antibody (8C8) is a mouse monoclonal IgG1 antibody that detects Bcl-2 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunohistochemistry. Bcl-2 is a crucial anti-apoptotic protein that plays a significant role in regulating apoptosis, which is vital for maintaining tissue homeostasis and protecting against diseases, including cancer. Located primarily in the outer mitochondrial membrane, Bcl-2′s strategic positioning allows direct inhibition of pro-apoptotic factor release, thereby preventing cell death. This localization enables Bcl-2 to interact with other members of the Bcl-2 family, such as Bax and Bak, which are key players in the apoptotic pathway. By stabilizing the mitochondrial membrane, Bcl-2 not only promotes cell survival but also contributes to the overall balance between cell proliferation and death, a process that, when disrupted, can lead to tumorigenesis. Anti-Bcl-2 antibody (8C8) serves as an invaluable tool for researchers studying the mechanisms of apoptosis and the implications of Bcl-2 in various diseases, particularly in understanding how dysregulation can lead to cancer progression.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Bcl-2 Antibody (8C8) | sc-65392 | 200 µg/ml | $322.00 | |||
Bcl-2 Antibody (8C8): m-IgG Fc BP-HRP Bundle | sc-539172 | 200 µg Ab; 10 µg BP | $361.00 |