BCAS2 Antibody (G-8): sc-365346
- BCAS2 Antibody (G-8) is a mouse monoclonal IgG3 κ, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 11-31 near the N-terminus of BCAS2 of human origin
- recommended for detection of BCAS2 of mouse, rat, human and avian origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine, porcine and avian
- m-IgG3 BP-HRP is the preferred secondary detection reagent for BCAS2 Antibody (G-8) for WB applications. This reagent is now offered in a bundle with BCAS2 Antibody (G-8) (see ordering information below).
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BCAS2 Antibody (G-8) is a mouse monoclonal IgG3 antibody that detects BCAS2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). BCAS2, also known as breast carcinoma amplified sequence 2 or DAM1 (DNA amplified in mammary carcinoma 1 protein), is a crucial nuclear protein that plays a significant role in the spliceosome, a complex responsible for removing introns from precursor mRNA. The proper functioning of the spliceosome is vital for gene expression regulation, as BCAS2 ensures that only the correct exons join together to form mature mRNA, which ultimately translates into functional proteins. Aberrations in splicing mechanisms can lead to various diseases, including cancer, highlighting BCAS2′s importance in maintaining cellular homeostasis. Additionally, BCAS2 interacts with several key proteins, including thyroid hormone receptor beta, estrogen receptors alpha and beta, progesterone receptor, and peroxisome proliferator-activated receptor gamma, functioning as a coactivator for estrogen receptors and enhancing transcriptional activity. This interaction underscores BCAS2′s potential role in breast cancer development, making BCAS2 a significant target for research and therapeutic strategies.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BCAS2 Antibody (G-8) | sc-365346 | 200 µg/ml | $316.00 | |||
BCAS2 Antibody (G-8): m-IgG3 BP-HRP Bundle | sc-550425 | 200 µg Ab; 40 µg BP | $354.00 | |||
BCAS2 (G-8) Neutralizing Peptide | sc-365346 P | 100 µg/0.5 ml | $68.00 |