BBS7 Antibody (E-8): sc-390403
- BBS7 Antibody (E-8) is a mouse monoclonal IgG1 λ BBS7 antibody, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 483-521 within an internal region of BBS7 of human origin
- BBS7 Antibody (E-8) is recommended for detection of BBS7 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and canine, bovine and porcine
- TransCruz reagent for ChIP application (sc-390403 X, 200 µg/0.1 ml)
- Anti-BBS7 Antibody (E-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgGλ BP-HRP (mouse IgGλ binding protein-HRP) is the preferred secondary detection reagent for BBS7 Antibody (E-8) for WB applications. This reagent is now offered in a bundle with BBS7 Antibody (E-8) (see ordering information below). For additional m-IgGλ BP conjugates see our complete list of Mouse IgG Binding Proteins.
BBS7 Antibody (E-8) is a mouse monoclonal IgG1 antibody that detects BBS7 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). BBS7 (E-8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. BBS7 plays a crucial role in the assembly and function of cilia, which are essential for various cellular processes, including signaling pathways and cellular motility. Dysfunction in cilia can lead to a range of disorders, collectively known as ciliopathies, which include Bardet-Biedl syndrome (BBS). BBS is a complex genetic disorder characterized by symptoms such as obesity, photoreceptor degeneration, polydactyly, hypogenitalism, renal abnormalities, and developmental delays. Patients with BBS are also at an increased risk for developing diabetes, hypertension, and congenital heart defects. BBS7, consisting of 672 amino acids, is expressed at low to moderate levels across most human tissues and is one of the eight proteins encoded by the BBS genes, which are mapped to eight genetic loci. Understanding BBS7 and its role in ciliary function is vital for elucidating the underlying mechanisms of BBS and developing potential therapeutic strategies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
BBS7 Antibody (E-8) References:
- Identification of the gene (BBS1) most commonly involved in Bardet-Biedl syndrome, a complex human obesity syndrome. | Mykytyn, K., et al. 2002. Nat Genet. 31: 435-8. PMID: 12118255
- Identification of a novel Bardet-Biedl syndrome protein, BBS7, that shares structural features with BBS1 and BBS2. | Badano, JL., et al. 2003. Am J Hum Genet. 72: 650-8. PMID: 12567324
- Ocular phenotypes of three genetic variants of Bardet-Biedl syndrome. | Héon, E., et al. 2005. Am J Med Genet A. 132A: 283-7. PMID: 15690372
- [Update on Bardet-Biedl syndrome]. | Dollfus, H., et al. 2005. J Fr Ophtalmol. 28: 106-12. PMID: 15767906
- Testing for triallelism: analysis of six BBS genes in a Bardet-Biedl syndrome family cohort. | Hichri, H., et al. 2005. Eur J Hum Genet. 13: 607-16. PMID: 15770229
- No evidence for triallelic inheritance of MKKS/BBS loci in Amish Mckusick-Kaufman syndrome. | Nakane, T. and Biesecker, LG. 2005. Am J Med Genet A. 138: 32-4. PMID: 16104012
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BBS7 Antibody (E-8) | sc-390403 | 200 µg/ml | $322.00 | |||
BBS7 Antibody (E-8): m-IgGλ BP-HRP Bundle | sc-523520 | 200 µg Ab, 40 µg BP | $361.00 | |||
BBS7 Antibody (E-8) X | sc-390403 X | 200 µg/0.1 ml | $322.00 | |||
BBS7 Antibody (E-8) AC | sc-390403 AC | 500 µg/ml, 25% agarose | $424.00 | |||
BBS7 Antibody (E-8) HRP | sc-390403 HRP | 200 µg/ml | $322.00 | |||
BBS7 Antibody (E-8) FITC | sc-390403 FITC | 200 µg/ml | $336.00 | |||
BBS7 Antibody (E-8) PE | sc-390403 PE | 200 µg/ml | $349.00 | |||
BBS7 Antibody (E-8) Alexa Fluor® 488 | sc-390403 AF488 | 200 µg/ml | $364.00 | |||
BBS7 Antibody (E-8) Alexa Fluor® 546 | sc-390403 AF546 | 200 µg/ml | $364.00 | |||
BBS7 Antibody (E-8) Alexa Fluor® 594 | sc-390403 AF594 | 200 µg/ml | $364.00 | |||
BBS7 Antibody (E-8) Alexa Fluor® 647 | sc-390403 AF647 | 200 µg/ml | $364.00 | |||
BBS7 Antibody (E-8) Alexa Fluor® 680 | sc-390403 AF680 | 200 µg/ml | $364.00 | |||
BBS7 Antibody (E-8) Alexa Fluor® 790 | sc-390403 AF790 | 200 µg/ml | $364.00 | |||
BBS7 (E-8) Neutralizing Peptide | sc-390403 P | 100 µg/0.5 ml | $69.00 |