BBS1 Antibody (F-1): sc-365138
- BBS1 Antibody (F-1) is a mouse monoclonal IgG1 κ BBS1 antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 291-590 mapping near the C-terminus of BBS1 of human origin
- BBS1 Antibody (F-1) is recommended for detection of BBS1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
- Anti-BBS1 Antibody (F-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- TransCruz reagent for ChIP application (sc-365138 X, 200 µg/0.1 ml)
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for BBS1 Antibody (F-1) for WB and IHC(P) applications. These reagents are now offered in bundles with BBS1 Antibody (F-1) (see ordering information below).
BBS1 Antibody (F-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects BBS1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). BBS1 Antibody (F-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. BBS1 plays a crucial role in the function of cilia, which are essential for various cellular processes, including signaling pathways and the maintenance of cellular homeostasis. Dysfunction in cilia can lead to a range of disorders, collectively known as ciliopathies, with Bardet-Biedl syndrome (BBS) being one of the most prominent examples. BBS is a complex genetic disorder characterized by symptoms such as obesity, photoreceptor degeneration, polydactyly, hypogenitalism, renal abnormalities, and developmental delays, and is associated with an increased risk of diabetes, hypertension, and congenital heart defects. BBS1 is expressed in various tissues, with the highest levels found in fetal tissues, testis, retina, and adipose tissue, highlighting BBS1′s importance in developmental processes. BBS1 is highly conserved across mammals and is inherited in an autosomal recessive manner, with missense mutations in BBS1 accounting for approximately 80% of all identified mutations related to Bardet-Biedl syndrome.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
BBS1 Antibody (F-1) References:
- Evaluation of complex inheritance involving the most common Bardet-Biedl syndrome locus (BBS1). | Mykytyn, K., et al. 2003. Am J Hum Genet. 72: 429-37. PMID: 12524598
- Heterozygous mutations in BBS1, BBS2 and BBS6 have a potential epistatic effect on Bardet-Biedl patients with two mutations at a second BBS locus. | Badano, JL., et al. 2003. Hum Mol Genet. 12: 1651-9. PMID: 12837689
- Linkage disequilibrium mapping in the Newfoundland population: a re-evaluation of the refinement of the Bardet-Biedl syndrome 1 critical interval. | Fan, Y., et al. 2005. Hum Genet. 116: 62-71. PMID: 15517396
- SEREX identification of new tumor antigens linked to melanoma-associated retinopathy. | Hartmann, TB., et al. 2005. Int J Cancer. 114: 88-93. PMID: 15523688
- Antenatal presentation of Bardet-Biedl syndrome may mimic Meckel syndrome. | Karmous-Benailly, H., et al. 2005. Am J Hum Genet. 76: 493-504. PMID: 15666242
- Ocular phenotypes of three genetic variants of Bardet-Biedl syndrome. | Héon, E., et al. 2005. Am J Med Genet A. 132A: 283-7. PMID: 15690372
- [Update on Bardet-Biedl syndrome]. | Dollfus, H., et al. 2005. J Fr Ophtalmol. 28: 106-12. PMID: 15767906
- Testing for triallelism: analysis of six BBS genes in a Bardet-Biedl syndrome family cohort. | Hichri, H., et al. 2005. Eur J Hum Genet. 13: 607-16. PMID: 15770229
- No evidence for triallelic inheritance of MKKS/BBS loci in Amish Mckusick-Kaufman syndrome. | Nakane, T. and Biesecker, LG. 2005. Am J Med Genet A. 138: 32-4. PMID: 16104012
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BBS1 Antibody (F-1) | sc-365138 | 200 µg/ml | $316.00 | |||
BBS1 Antibody (F-1): m-IgG Fc BP-HRP Bundle | sc-527335 | 200 µg Ab; 10 µg BP | $354.00 | |||
BBS1 Antibody (F-1): m-IgG1 BP-HRP Bundle | sc-532708 | 200 µg Ab; 20 µg BP | $354.00 | |||
BBS1 Antibody (F-1) X | sc-365138 X | 200 µg/0.1 ml | $316.00 | |||
BBS1 Antibody (F-1) AC | sc-365138 AC | 500 µg/ml, 25% agarose | $416.00 | |||
BBS1 Antibody (F-1) HRP | sc-365138 HRP | 200 µg/ml | $316.00 | |||
BBS1 Antibody (F-1) FITC | sc-365138 FITC | 200 µg/ml | $330.00 | |||
BBS1 Antibody (F-1) PE | sc-365138 PE | 200 µg/ml | $343.00 | |||
BBS1 Antibody (F-1) Alexa Fluor® 488 | sc-365138 AF488 | 200 µg/ml | $357.00 | |||
BBS1 Antibody (F-1) Alexa Fluor® 546 | sc-365138 AF546 | 200 µg/ml | $357.00 | |||
BBS1 Antibody (F-1) Alexa Fluor® 594 | sc-365138 AF594 | 200 µg/ml | $357.00 | |||
BBS1 Antibody (F-1) Alexa Fluor® 647 | sc-365138 AF647 | 200 µg/ml | $357.00 | |||
BBS1 Antibody (F-1) Alexa Fluor® 680 | sc-365138 AF680 | 200 µg/ml | $357.00 | |||
BBS1 Antibody (F-1) Alexa Fluor® 790 | sc-365138 AF790 | 200 µg/ml | $357.00 |