Batrachotoxin (CAS 23509-16-2)

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Alternate Names: BTX

Application: Batrachotoxin is a neurotoxic voltage-gated Na+ channel activator

CAS Number: 23509-16-2

Purity: ≥90%

Molecular Weight: 538.68

Molecular Formula: C₃₁H₄₂N₂O₆

Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

* Refer to Certificate of Analysis for lot specific data (including water content).

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SDS & Certificate of Analysis

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Batrachotoxin is a toxic steroidal alkaloid, which is found in neotropical poison dart frogs from the genus, Phyllobates. It is known that Batrachotoxin specifically activates sodium channel protein (voltage gated Na⁺ channels) in the peripheral nervous system, which increase membrane permeability. This alters ion selectivity, prevents channel inactivation, and promotes single channel conductance. Studies determined that the binding site of Batrachotoxin is located within the inner cavity of the voltage gated channel. In addition, the residue hNa(v)1.5-N927 is critical for ion permeation when Batrachotoxin is bound.

References

1. Brown, G.B. 1988. Int. Rev. Neurobiol. 29: 77-116. PMID: 2456998
2. Wang, S.Y., et al. 2006. Mol. Pharmacol. 69: 788-795. PMID: 16354762
3. Wang, S.Y., et al. 2007. Channels 1: 179-188. PMID: 18690024

Appearance :

Film

Physical State :

Solid

Solubility :

Soluble in DMSO, ethanol, and methanol.

Storage :

Store at -20° C

Boiling Point :

~744.0° C at 760 mmHg (Predicted)

Density :

~1.3 g/cm³ (Predicted)

Refractive Index :

n²⁰_D 1.64 (Predicted)

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

RTECS :

CR3990000

Transport :

Not available for sale outside of the United States.

PubChem CID :

31958

Merck Index :

14: 1009

SMILES :

CC1=CNC(=C1C(=O)OC(C)C2=CC[[email protected]@]34C2(C[[email protected]](C56C3=CC[[email protected]]7[[email protected]@]5(CC[[email protected]@](C7)(O6)O)C)O)CN(CCO4)C)C

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Certificate of Analysis

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Hi is the baratoxin sold to individuals or just companies or organization? Thank you Stacey

Asked by: stacey05

Thank you for your question. It would be helpful if you could call us directly at 800-457-3801 ext. 1, allowing for a more interactive discussion of this and other related questions.

Answered by: Blake J

Date published: 2021-09-22

Hola buenas tardes me pued s dar el costo y el tiempo de entrega

Asked by: Anonymous

Thank you for your question. Please contact one of our authorized distributors for information about current product availability and shipping lead times.

Answered by: Technical Support

Date published: 2021-07-04

Hello do u ship in india

Asked by: Gajju

Thank you for your question. Please contact one of our authorized distributors to product availability and shipping lead times.

Answered by: Technical Support

Date published: 2020-02-25

hello, do you ship to the netherlands also?

Asked by: isildur 30

Thank you for your question. Unfortunately, we do not ship this product internationally.

Answered by: Santa Cruz TS

Date published: 2018-08-14

I want to ask you for a formal quotation of BTX CAS 23509-16-2 and importation permissions needed for Colombia. Thanks for your attention

Asked by: Mabel

Thank you for your question. Please contact one of our authorized distributors in Colombia for a formal quotation for this chemical, Batrachotoxin (CAS 23509-16-2). A link to search for our distributors is provided below. https://www.scbt.com/scbt/resources/distributors

Answered by: Technical Support

Date published: 2021-03-22

Rated 5 out of 5 by HF from Du Y; et al Du Y; et al. (PubMed ID: 21680776) determined that Batrachotoxin, a sodium ion channel agonist, has a receptor site that overlaps with that of (2E,4E)-N-(1,2-dimethylpropyl)-6-(5-bromo-2-naphthalenyl)-2,4-hexadienamide on sodium ion channels. -SCBT Publication Review

Date published: 2015-05-29

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