BATF2 Antibody (1B11): sc-293274

BATF2 Antibody (1B11) is a mouse monoclonal IgG2b kappa light chain antibody that detects BATF2 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-BATF2 antibody (1B11) is available as the non-conjugated format. BATF2, also known as basic leucine zipper transcription factor, ATF-like 2, is a 274 amino acid protein that plays a crucial role in the regulation of gene expression by binding to specific DNA sequences in the nucleus, where BATF2 is primarily localized. BATF2 is essential for various cellular processes, including immune response and cell differentiation, making BATF2 vital for maintaining proper immune function and potentially influencing the development of autoimmune diseases. The gene encoding BATF2 is located on human chromosome 11, which is known for its dense gene and disease associations, comprising approximately 4% of human genomic DNA. Mutations in genes located on this chromosome can lead to various disorders, highlighting the significance of BATF2 in the broader context of genetic regulation and disease. Through interactions with other transcription factors and regulatory proteins, BATF2 is integral to the transcriptional networks that govern cellular responses, making BATF2 a significant target for research in immunology and related fields.

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BATF2 Antibody (1B11) References:

1. Identification and characterization of human TP53I5 and mouse Tp53i5 genes in silico.  |  Katoh, M. and Katoh, M. 2004. Int J Oncol. 25: 225-30. PMID: 15202010
2. The 11q terminal deletion disorder: a prospective study of 110 cases.  |  Grossfeld, PD., et al. 2004. Am J Med Genet A. 129A: 51-61. PMID: 15266616
3. Human chromosome 11 DNA sequence and analysis including novel gene identification.  |  Taylor, TD., et al. 2006. Nature. 440: 497-500. PMID: 16554811
4. KCNQ1 K+ channel-mediated cardiac channelopathies.  |  Loussouarn, G., et al. 2006. Methods Mol Biol. 337: 167-83. PMID: 16929947
5. Skipping of Exon 1 in the KCNQ1 gene causes Jervell and Lange-Nielsen syndrome.  |  Zehelein, J., et al. 2006. J Biol Chem. 281: 35397-403. PMID: 16987820
6. Beta-thalassaemia and sickle cell anaemia as paradigms of hypercoagulability.  |  Ataga, KI., et al. 2007. Br J Haematol. 139: 3-13. PMID: 17854302
7. The subcellular localization of the Niemann-Pick Type C proteins depends on the adaptor complex AP-3.  |  Berger, AC., et al. 2007. J Cell Sci. 120: 3640-52. PMID: 17895371
8. BATF2 promotes HSC myeloid differentiation by amplifying IFN response mediators during chronic infection.  |  Le, DT., et al. 2023. iScience. 26: 106059. PMID: 36824275
9. BATF2 enhances proinflammatory cytokine responses in macrophages and improves early host defense against pulmonary Klebsiella pneumoniae infection.  |  van der Geest, R., et al. 2023. Am J Physiol Lung Cell Mol Physiol. 325: L604-L616. PMID: 37724373
10. BATF2 inhibits PD-L1 expression and regulates CD8+ T-cell infiltration in non-small cell lung cancer.  |  Liu, J., et al. 2023. J Biol Chem. 299: 105302. PMID: 37777155
11. CD36-BATF2\MYB Axis Predicts Anti-PD-1 Immunotherapy Response in Gastric Cancer.  |  Jiang, Q., et al. 2023. Int J Biol Sci. 19: 4476-4492. PMID: 37781029
12. A model for p53-induced apoptosis.  |  Polyak, K., et al. 1997. Nature. 389: 300-5. PMID: 9305847

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-BATF2 Antibody (1B11) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-BATF2 Antibody (1B11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

BATF2 Antibody (1B11) Specifications

Alternate Product Name: BATF2

Product Clone Name: 1B11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 1-189

Epitope Target: BATF2

Epitope Species: human

Product Reactivity/Detection: BATF2

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for BATF2 Antibody (1B11): N/A