bassoon Antibody (SAP7F407): sc-58509

Bassoon Antibody (SAP7F407) is a mouse monoclonal IgG2a kappa light chain antibody that detects bassoon protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-bassoon antibody (SAP7F407) is available as a non-conjugated format. Bassoon protein plays a critical role in the organization of the presynaptic cytomatrix, which is essential for efficient neurotransmitter release at synapses. Bassoon (SAP7F407) antibody targets a large protein predominantly located in axon terminals of hippocampal neurons, where bassoon protein is highly concentrated near the active zone, facilitating synaptic transmission. Bassoon protein works in concert with another presynaptic protein, Piccolo, to orchestrate complex events that occur at the nerve terminal, ensuring proper synaptic function. The interaction between bassoon and Piccolo is vital for maintaining structural integrity of the presynaptic compartment, and disruptions in this interaction can lead to synaptic dysfunction, which is implicated in various neurological disorders. The gene encoding bassoon is located on human chromosome 3p21.31, while the gene for Piccolo is found on chromosome 7q21.11, highlighting the importance of these proteins in the genetic landscape of synaptic biology.

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bassoon Antibody (SAP7F407) References:

1. The presynaptic cytomatrix protein Bassoon: sequence and chromosomal localization of the human BSN gene.  |  Winter, C., et al. 1999. Genomics. 57: 389-97. PMID: 10329005
2. Piccolo, a presynaptic zinc finger protein structurally related to bassoon.  |  Fenster, SD., et al. 2000. Neuron. 25: 203-14. PMID: 10707984
3. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro.  |  Ishikawa, K., et al. 1997. DNA Res. 4: 307-13. PMID: 9455477
4. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.  |  Nagase, T., et al. 1998. DNA Res. 5: 31-9. PMID: 9628581
5. Bassoon, a novel zinc-finger CAG/glutamine-repeat protein selectively localized at the active zone of presynaptic nerve terminals.  |  tom Dieck, S., et al. 1998. J Cell Biol. 142: 499-509. PMID: 9679147
6. Cloning and mapping of ZNF231, a novel brain-specific gene encoding neuronal double zinc finger protein whose expression is enhanced in a neurodegenerative disorder, multiple system atrophy (MSA).  |  Hashida, H., et al. 1998. Genomics. 54: 50-8. PMID: 9806829

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-bassoon Antibody (SAP7F407) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-bassoon Antibody (SAP7F407) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

bassoon Antibody (SAP7F407) Specifications

Alternate Product Name: bassoon

Product Clone Name: SAP7F407

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids:

Epitope Target: bassoon

Epitope Species: rat

Product Reactivity/Detection: bassoon

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: bovine and canine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for bassoon Antibody (SAP7F407): N/A