Barx1 Antibody (392.8): sc-81956

Barx1 Antibody (392.8) is a mouse monoclonal IgG1 kappa light chain antibody that detects Barx1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Barx1 antibody (392.8) is available as the non-conjugated form. The BAR homeobox (Barx) family, which includes Barx1 and Barx2, plays a crucial role in regulating place-dependent morphogenesis and controlling the expression patterns of cell adhesion molecules. Barx1, a 226-amino acid nuclear protein, is predominantly expressed in the testis, heart, and craniofacial tissues, where Barx1 functions as a homeodomain transcription factor essential for odontogenesis, craniofacial development, and stomach organogenesis. Notably, Barx1 is involved in the regulation of mesenchymal cell expression of two secreted Wnt antagonists, sFRP1 and sFRP2, which are vital for the development of the gastric endoderm prior to epithelial differentiation. During the early stages of molar development, Barx1 directs undetermined ectomesenchymal cells in the proximal region of the jaws to follow the pathway of multicuspid tooth development. Additionally, Barx1 expression is stimulated by fibroblast growth factor-8 (FGF8) while being inhibited by bone morphogenetic protein-4 (BMP4), highlighting Barx1′s intricate role in developmental signaling pathways.

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Barx1 Antibody (392.8) References:

1. Cloning, characterization, localization, and mutational screening of the human BARX1 gene.  |  Gould, DB. and Walter, MA. 2000. Genomics. 68: 336-42. PMID: 10995576
2. Expression of the homeobox gene barx2 in the gut.  |  Sander, GR. and Powell, BC. 2004. J Histochem Cytochem. 52: 541-4. PMID: 15034005
3. Mutational analysis of BARHL1 and BARX1 in three new patients with Joubert syndrome.  |  Gould, DB. and Walter, MA. 2004. Am J Med Genet A. 131: 205-8. PMID: 15487006
4. The pro-apoptotic activity of a vertebrate Bar-like homeobox gene plays a key role in patterning the Xenopus neural plate by limiting the number of chordin- and shh-expressing cells.  |  Offner, N., et al. 2005. Development. 132: 1807-18. PMID: 15772136
5. The stomach mesenchymal transcription factor Barx1 specifies gastric epithelial identity through inhibition of transient Wnt signaling.  |  Kim, BM., et al. 2005. Dev Cell. 8: 611-22. PMID: 15809042
6. Barx1 and evolutionary changes in feeding.  |  Miletich, I., et al. 2005. J Anat. 207: 619-22. PMID: 16313395
7. Barx1, a new mouse homeodomain transcription factor expressed in cranio-facial ectomesenchyme and the stomach.  |  Tissier-Seta, JP., et al. 1995. Mech Dev. 51: 3-15. PMID: 7669690
8. Expression of the transcription factors Otlx2, Barx1 and Sox9 during mouse odontogenesis.  |  Mitsiadis, TA., et al. 1998. Eur J Oral Sci. 106 Suppl 1: 112-6. PMID: 9541211

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Barx1 Antibody (392.8) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-Barx1 Antibody (392.8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Barx1 Antibody (392.8) Specifications

Alternate Product Name: Barx1

Product Clone Name: 392.8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-101

Epitope Target: Barx1

Epitope Species: human

Product Reactivity/Detection: Barx1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 50 µg IgG₁ kappa light chain in 0.5 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for Barx1 Antibody (392.8): N/A