Bag-2 Antibody (A-12): sc-101216
- Bag-2 Antibody (A-12) is a mouse monoclonal IgG1 κ, cited in 3 publications, provided at 100 µg/ml
- raised against recombinant Bag-2 of human origin
- recommended for detection of Bag-2 of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Bag-2 Antibody (A-12). This work is in progress.
Bag-2 Antibody (A-12) is a mouse monoclonal IgG1 antibody that detects Bag-2 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Bag-2, also known as Bcl-2-associated athanogene 2 or Bag family molecular chaperone regulator 2, plays a crucial role in cellular processes by functioning as a co-chaperone for HSC 70, a heat shock protein that assists in protein folding and protection against stress-induced damage. Anti-Bag-2 antibody (A-12) enables research into Bag-2′s ability to regulate apoptosis and chaperone activity, which is vital for maintaining cellular homeostasis and preventing diseases such as cancer. Located primarily in the cytoplasm, Bag-2 interacts with the ATPase domain of HSC 70 and the U-box domain of CHIP, forming a chaperone-dependent ubiquitin ligase complex that modulates protein degradation pathways. By inhibiting the ubiquitylation process, Bag-2 ensures the stability of client proteins, thereby influencing various signaling pathways and cellular responses. Bag-2 monoclonal antibody (A-12) serves as an essential tool for researchers studying the intricate mechanisms of protein homeostasis and the implications of chaperone interactions in health and disease.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Bag-2 Antibody (A-12) | sc-101216 | 100 µg/ml | $339.00 |