B7-1 Antibody (3H1697): sc-70394

B7-1 Antibody (3H1697) is a mouse monoclonal IgG1 antibody that detects B7-1 in mouse and rat samples through immunoprecipitation (IP) and flow cytometry (FCM) applications. B7-1 (CD80) plays a crucial role in the immune response by providing essential costimulatory signals necessary for T cell activation. B7-1 (CD80) is primarily located on the surface of antigen-presenting cells, where B7-1 (CD80) interacts with the receptors CTLA-4 and CD28 on T cells, thereby influencing T cell proliferation and cytokine production. The interaction between B7-1 (CD80) and CD28 enhances T cell activation, while B7-1 (CD80) binding to CTLA-4 serves as a negative regulatory signal, helping to maintain immune homeostasis. Understanding the dynamics of B7-1′s function and interactions is vital for developing therapeutic strategies aimed at modulating immune responses in various diseases, including cancer and autoimmune disorders. Anti-B7-1 antibody (3H1697) serves as an invaluable tool for researchers investigating these complex immune mechanisms.

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B7-1 Antibody (3H1697) References:

1. B7-1 and B7-2 co-stimulatory molecules are required for mercury-induced autoimmunity.  |  Bagenstose, LM., et al. 2002. Clin Exp Immunol. 127: 12-9. PMID: 11882027
2. B7-1 mediated costimulation regulates pancreatic autoimmunity.  |  Yadav, D., et al. 2007. Mol Immunol. 44: 2616-24. PMID: 17289146
3. Abatacept in B7-1-positive proteinuric kidney disease.  |  Greka, A., et al. 2014. N Engl J Med. 370: 1263-6. PMID: 24670178
4. Role of podocyte B7-1 in diabetic nephropathy.  |  Fiorina, P., et al. 2014. J Am Soc Nephrol. 25: 1415-29. PMID: 24676639
5. B7-1 immunostaining in proteinuric kidney disease.  |  Larsen, CP., et al. 2014. Am J Kidney Dis. 64: 1001-3. PMID: 25278092
6. The costimulatory receptor B7-1 is not induced in injured podocytes.  |  Baye, E., et al. 2016. Kidney Int. 90: 1037-1044. PMID: 27528551
7. Mechanistic dissection of the PD-L1:B7-1 co-inhibitory immune complex.  |  Garrett-Thomson, SC., et al. 2020. PLoS One. 15: e0233578. PMID: 32497097
8. Co-expression of B7-1 and ICAM-1 on tumors is required for rejection and the establishment of a memory response.  |  Cavallo, F., et al. 1995. Eur J Immunol. 25: 1154-62. PMID: 7539748
9. B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation.  |  Borriello, F., et al. 1997. Immunity. 6: 303-13. PMID: 9075931
10. Effects of blocking B7-1 and B7-2 interactions during a type 2 in vivo immune response.  |  Greenwald, RJ., et al. 1997. J Immunol. 158: 4088-96. PMID: 9126967

The preferred B7-1 antibody is B7-1 Antibody (F-7): sc-376012.