ATP13A2 Antibody (4B7): sc-293367

ATP13A2 Antibody (4B7) is a mouse monoclonal IgG2a kappa light chain antibody that detects ATP13A2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). ATP13A2 (4B7) antibody is available as a non-conjugated anti-ATP13A2 monoclonal isotype antibody. ATP13A2, also known as ATPase type 13A2, KRPPD, PARK9, or HSA9947, is a crucial 1,180 amino acid multi-pass membrane protein that belongs to the P5 subfamily of ATPases, which are essential for the transportation of inorganic cations across cellular membranes. ATP13A2 is primarily located in the lysosomal membrane, where ATP13A2 plays a vital role in maintaining cellular ion homeostasis and regulating the transport of metal ions, such as manganese and zinc. Proper functioning of ATP13A2 is critical, as disruptions in ATP13A2 activity can lead to the accumulation of toxic metals within cells, contributing to neurodegenerative diseases, including Kufor-Rakeb syndrome, a rare hereditary form of Parkinson′s disease characterized by early-onset neurodegeneration and dementia. ATP13A2 gene is located on human chromosome 1, which encompasses a large portion of the human genome, containing over 3,000 genes and spanning 260 million base pairs, highlighting the complexity and importance of genetic regulation in health and disease.

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ATP13A2 Antibody (4B7) References:

1. Kufor-Rakeb syndrome, pallido-pyramidal degeneration with supranuclear upgaze paresis and dementia, maps to 1p36.  |  Hampshire, DJ., et al. 2001. J Med Genet. 38: 680-2. PMID: 11584046
2. Characterization of the P5 subfamily of P-type transport ATPases in mice.  |  Schultheis, PJ., et al. 2004. Biochem Biophys Res Commun. 323: 731-8. PMID: 15381061
3. Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase.  |  Ramirez, A., et al. 2006. Nat Genet. 38: 1184-91. PMID: 16964263
4. ATP13A2 missense mutations in juvenile parkinsonism and young onset Parkinson disease.  |  Di Fonzo, A., et al. 2007. Neurology. 68: 1557-62. PMID: 17485642
5. PARK9-linked parkinsonism in eastern Asia: mutation detection in ATP13A2 and clinical phenotype.  |  Ning, YP., et al. 2008. Neurology. 70: 1491-3. PMID: 18413573
6. Novel ATP13A2 variant associated with Parkinson disease in Taiwan and Singapore.  |  Lin, CH., et al. 2008. Neurology. 71: 1727-32. PMID: 19015489
7. ATP13A2 variability in Parkinson disease.  |  Vilariño-Güell, C., et al. 2009. Hum Mutat. 30: 406-10. PMID: 19085912
8. Genetic association study of the P-type ATPase ATP13A2 in late-onset Parkinson's disease.  |  Rakovic, A., et al. 2009. Mov Disord. 24: 429-33. PMID: 19097176

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ATP13A2 Antibody (4B7) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-ATP13A2 Antibody (4B7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ATP13A2 Antibody (4B7) Specifications

Alternate Product Name: ATP13A2

Product Clone Name: 4B7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 68-154

Epitope Target: ATP13A2

Epitope Species: human

Product Reactivity/Detection: ATP13A2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for ATP13A2 Antibody (4B7): N/A