Atg4D Antibody (222CT15.4.1): sc-517312
- Atg4D Antibody (222CT15.4.1) is a mouse monoclonal IgG1 κ Atg4D antibody provided at 100 µg/ml
- raised against a recombinant protein corresponding to Atg4D of human origin
- recommended for detection of Atg4D of human origin by WB and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Atg4D Antibody (222CT15.4.1). This work is in progress.
Atg4D Antibody (222CT15.4.1) is a mouse monoclonal IgG1 kappa light chain antibody that detects the Atg4D protein of human origin by western blotting (WB) and immunofluorescence (IF). Anti-Atg4D antibody (222CT15.4.1) is available as a non-conjugated format. Atg4D, also known as autophagy-related gene 4D, APG4D, or AUTL4, is a crucial 474 amino acid protein that plays a significant role in autophagy, which is essential for cellular homeostasis and degradation of damaged organelles and proteins. Atg4D protein is primarily localized in the cytoplasm and predominantly expressed in skeletal muscle, with additional presence in the testis. As a member of the C-54 family of cysteine proteases, Atg4D protein is responsible for cleaving the C-terminal region of target proteins, a critical step that facilitates their binding to autophagosomes, thereby promoting the formation of these double-membrane vesicles necessary for autophagy. Atg4D enzymatic activity can be inhibited by N-ethylmaleimide, a compound that modifies cysteine residues, potentially disrupting the autophagic process, highlighting Atg4D′s importance in maintaining cellular health and potential implications in various diseases where autophagy is dysregulated.
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Atg4D Antibody (222CT15.4.1) References:
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- Autophagy--is it a preferred route for lifespan extension? | Dwivedi, M. and Ahnn, J. 2009. BMB Rep. 42: 62-71. PMID: 19250605
- Role of autophagy in mammary gland development. | Gajewska, M., et al. 2008. J Physiol Pharmacol. 59 Suppl 9: 237-49. PMID: 19261983
- Autophagy: molecular machinery, regulation, and implications for renal pathophysiology. | Periyasamy-Thandavan, S., et al. 2009. Am J Physiol Renal Physiol. 297: F244-56. PMID: 19279132
- Autophagy mediates the mitotic senescence transition. | Young, AR., et al. 2009. Genes Dev. 23: 798-803. PMID: 19279323
- Autophagy genes mediate the effect of calcineurin on life span in C. elegans. | Dwivedi, M., et al. 2009. Autophagy. 5: 604-7. PMID: 19279398
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Atg4D Antibody (222CT15.4.1) | sc-517312 | 100 µg/ml | $316.00 |