Atg2A Antibody (G-1): sc-514207

Atg2A Antibody (G-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects Atg2A of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-Atg2A antibody (G-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Atg2A, also known as TG2 autophagy related 2 homolog A, is a 1,938 amino acid protein that belongs to the ATG2 family and plays a crucial role in vesicle assembly, essential for the autophagy process. Atg2A is encoded by a gene located on human chromosome 11q13.1 and is conserved across several species, including chimpanzees, dogs, cows, mice, and rats, existing in four alternatively spliced isoforms. Atg2A is undetected in adult tissues such as the heart, brain, placenta, lung, liver, and skeletal muscle, indicating regulation may serve as a distinct marker for autophagic programmed cell death. Atg2A is upregulated during etoposide- and doxorubicin-induced apoptosis in HeLa cells, suggesting potential as a novel biomarker for topoisomerase II inhibitor-mediated apoptosis. Atg2A and Atg2B interaction highlights the functional relationship between these two proteins, which may further elucidate their roles in autophagy. Additionally, frameshift mutations in Atg2A have been associated with gastric and colorectal carcinomas exhibiting high microsatellite instability, indicating that alterations may contribute to cancer development by disrupting the autophagy process.

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Atg2A Antibody (G-1) References:

1. Evolutionary dynamics of multilocus microsatellite arrangements in the genome of the butterfly Bicyclus anynana, with implications for other Lepidoptera.  |  Van't Hof, AE., et al. 2007. Heredity (Edinb). 98: 320-8. PMID: 17327875
2. The cell biology of autophagy in metazoans: a developing story.  |  Meléndez, A. and Neufeld, TP. 2008. Development. 135: 2347-60. PMID: 18567846
3. Frameshift mutations of autophagy-related genes ATG2B, ATG5, ATG9B and ATG12 in gastric and colorectal cancers with microsatellite instability.  |  Kang, MR., et al. 2009. J Pathol. 217: 702-6. PMID: 19197948
4. Comprehensive analysis of expression pattern and promoter regulation of human autophagy-related genes.  |  Kusama, Y., et al. 2009. Apoptosis. 14: 1165-75. PMID: 19657746
5. Network organization of the human autophagy system.  |  Behrends, C., et al. 2010. Nature. 466: 68-76. PMID: 20562859
6. Integrative systems biology and networks in autophagy.  |  Ng, AC. 2010. Semin Immunopathol. 32: 355-61. PMID: 20842363
7. Tissue-specific regulation of mouse microRNA genes in endoderm-derived tissues.  |  Gao, Y., et al. 2011. Nucleic Acids Res. 39: 454-63. PMID: 20843784

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Atg2A Antibody (G-1) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Atg2A Antibody (G-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Atg2A Antibody (G-1) Specifications

Alternate Product Name: Atg2A

Product Clone Name: G-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 26-43

Epitope Target: Atg2A

Epitope Species: human

Product Reactivity/Detection: Atg2A

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Atg2A Antibody (G-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin