TRIM29 Antibody (B-2): sc-166707

TRIM29 Antibody (B-2) is a mouse monoclonal IgG2a kappa light chain antibody that detects TRIM29 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). anti-TRIM29 antibody (B-2) is available in both non-conjugated and multiple conjugated forms, such as agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and various Alexa Fluor® conjugates. TRIM29, also known as ATDC, plays a crucial role in cellular processes, particularly in the regulation of cell growth and differentiation, which is vital for maintaining normal cellular function and preventing tumorigenesis. TRIM29 has been implicated in the pathogenesis of ataxia-telangiectasia, a genetic disorder that significantly increases the risk of cancer and immune system defects. TRIM29 is located in the cytoplasm and has been shown to interact with vimentin, an intermediate filament protein, which is essential for maintaining cellular integrity and structure. The presence of both zinc finger and leucine zipper motifs in TRIM29 suggests potential to form homodimers and interact with DNA, further emphasizing importance in gene regulation and cellular response to stress.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

TRIM29 Antibody (B-2) References:

1. Cloning of a candidate gene for ataxia-telangiectasia group D.  |  Kapp, LN., et al. 1992. Am J Hum Genet. 51: 45-54. PMID: 1609804
2. The product of the ataxia-telangiectasia group D complementing gene, ATDC, interacts with a protein kinase C substrate and inhibitor.  |  Brzoska, PM., et al. 1995. Proc Natl Acad Sci U S A. 92: 7824-8. PMID: 7644499
3. Expression of the candidate A-T gene ATDC is not detectable in a human cell line with a normal response to ionizing radiation.  |  Murnane, JP., et al. 1994. Int J Radiat Biol. 66: S77-84. PMID: 7836856
4. Nucleotide sequence analysis of a candidate gene for ataxia-telangiectasia group D (ATDC).  |  Leonhardt, EA., et al. 1994. Genomics. 19: 130-6. PMID: 8188213
5. A radiation hybrid map of human chromosome 11q22-q23 containing the ataxia-telangiectasia disease locus.  |  Richard, CW., et al. 1993. Genomics. 17: 1-5. PMID: 8406440
6. Ataxia-telangiectasia and cellular responses to DNA damage.  |  Meyn, MS. 1995. Cancer Res. 55: 5991-6001. PMID: 8521380
7. Leukemia and lymphoma in ataxia telangiectasia.  |  Taylor, AM., et al. 1996. Blood. 87: 423-38. PMID: 8555463

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TRIM29 Antibody (B-2) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-TRIM29 Antibody (B-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TRIM29 Antibody (B-2) Specifications

Alternate Product Name: ATDC

Product Clone Name: B-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 289-588

Epitope Target: TRIM29

Epitope Species: human

Product Reactivity/Detection: TRIM29

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for TRIM29 Antibody (B-2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin