Ataxin-10 Antibody (C-3): sc-271233
- Ataxin-10 Antibody (C-3) is a mouse monoclonal IgG1 κ Ataxin-10 antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 15-190 mapping near the N-terminus of Ataxin-10 of human origin
- Ataxin-10 Antibody (C-3) is recommended for detection of Ataxin-10 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-Ataxin-10 Antibody (C-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Ataxin-10 Antibody (C-3) for WB and IHC(P) applications. These reagents are now offered in bundles with Ataxin-10 Antibody (C-3) (see ordering information below).
Ataxin-10 Antibody (C-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects ATAXIN-10 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-ATAXIN-10 antibody (C-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ATAXIN-10 plays a crucial role in the central nervous system, particularly in the cerebellum, brain stem, and spinal cord, where ATAXIN-10 is primarily expressed. As a cytoplasmic protein belonging to the armadillo repeat protein family, ATAXIN-10 is involved in important cellular processes, including the regulation of apoptosis in cerebellar neurons. A loss of ATAXIN-10 in primary neuronal cells has been linked to increased apoptosis, highlighting ATAXIN-10′s significance in neuronal survival and function. ATAXIN-10 interacts with p110, an O-Linked beta-N-acetylglucosamine transferase, suggesting ATAXIN-10′s potential role in modulating intracellular glycosylation levels and maintaining homeostasis in the brain. ATAXIN-10′s relevance is underscored by ATAXIN-10′s association with spinocerebellar ataxia type 10 (SCA10), an autosomal dominant disorder characterized by cerebellar ataxia and seizures, which arises from the expansion of an ATTCT pentanucleotide repeat in intron 9 of the ataxin-10 gene.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ataxin-10 Antibody (C-3) References:
- Ataxin-10, the spinocerebellar ataxia type 10 neurodegenerative disorder protein, is essential for survival of cerebellar neurons. | März, P., et al. 2004. J Biol Chem. 279: 35542-50. PMID: 15201271
- Clinical phenotype of Brazilian families with spinocerebellar ataxia 10. | Teive, HA., et al. 2004. Neurology. 63: 1509-12. PMID: 15505178
- FXTAS, SCA10, and SCA17 in American patients with movement disorders. | Seixas, AI., et al. 2005. Am J Med Genet A. 136: 87-9. PMID: 15889413
- Recent progress in spinocerebellar ataxia type-10 (SCA10). | Lin, X. and Ashizawa, T. 2005. Cerebellum. 4: 37-42. PMID: 15895557
- The AUUCU repeats responsible for spinocerebellar ataxia type 10 form unusual RNA hairpins. | Handa, V., et al. 2005. J Biol Chem. 280: 29340-5. PMID: 15970586
- Conformational analysis in solution of protein kinase C betaII V5-1 peptide. | Shin, C., et al. 2005. Biochem Biophys Res Commun. 337: 154-9. PMID: 16182252
- Interruptions in the expanded ATTCT repeat of spinocerebellar ataxia type 10: repeat purity as a disease modifier? | Matsuura, T., et al. 2006. Am J Hum Genet. 78: 125-9. PMID: 16385455
- Ataxin-10 interacts with O-linked beta-N-acetylglucosamine transferase in the brain. | März, P., et al. 2006. J Biol Chem. 281: 20263-70. PMID: 16714295
- The role of ataxin 10 in the pathogenesis of spinocerebellar ataxia type 10. | Wakamiya, M., et al. 2006. Neurology. 67: 607-13. PMID: 16924013
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ataxin-10 Antibody (C-3) | sc-271233 | 200 µg/ml | $322.00 | |||
Ataxin-10 Antibody (C-3): m-IgG Fc BP-HRP Bundle | sc-527221 | 200 µg Ab; 10 µg BP | $361.00 | |||
Ataxin-10 Antibody (C-3): m-IgG1 BP-HRP Bundle | sc-532594 | 200 µg Ab; 20 µg BP | $361.00 | |||
Ataxin-10 Antibody (C-3) AC | sc-271233 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Ataxin-10 Antibody (C-3) HRP | sc-271233 HRP | 200 µg/ml | $322.00 | |||
Ataxin-10 Antibody (C-3) FITC | sc-271233 FITC | 200 µg/ml | $336.00 | |||
Ataxin-10 Antibody (C-3) PE | sc-271233 PE | 200 µg/ml | $349.00 | |||
Ataxin-10 Antibody (C-3) Alexa Fluor® 488 | sc-271233 AF488 | 200 µg/ml | $364.00 | |||
Ataxin-10 Antibody (C-3) Alexa Fluor® 546 | sc-271233 AF546 | 200 µg/ml | $364.00 | |||
Ataxin-10 Antibody (C-3) Alexa Fluor® 594 | sc-271233 AF594 | 200 µg/ml | $364.00 | |||
Ataxin-10 Antibody (C-3) Alexa Fluor® 647 | sc-271233 AF647 | 200 µg/ml | $364.00 | |||
Ataxin-10 Antibody (C-3) Alexa Fluor® 680 | sc-271233 AF680 | 200 µg/ml | $364.00 | |||
Ataxin-10 Antibody (C-3) Alexa Fluor® 790 | sc-271233 AF790 | 200 µg/ml | $364.00 |