ASPHD2 Antibody (E-9): sc-390986
- ASPHD2 Antibody (E-9) is a mouse monoclonal IgG1 κ ASPHD2 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 101-122 within an internal region of ASPHD2 of human origin
- ASPHD2 Antibody (E-9) is recommended for detection of ASPHD2 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine
- Anti-ASPHD2 Antibody (E-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for ASPHD2 Antibody (E-9) for WB applications. These reagents are now offered in bundles with ASPHD2 Antibody (E-9) (see ordering information below).
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ASPHD2 Antibody (E-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects ASPHD2 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ASPHD2 monoclonal antibody (E-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ASPHD2, or aspartate beta-hydroxylase domain containing 2, is a 369 amino acid single-pass type II membrane protein that plays a crucial role in the hydroxylation of aspartate residues, which is essential for the proper functioning of various proteins and signaling pathways. This post-translational modification influences protein stability, activity, and interactions, thereby impacting cellular processes such as differentiation and response to stress. ASPHD2 is encoded by a gene located on human chromosome 22q12.1, a region associated with several genetic disorders, including Phelan-McDermid syndrome and neurofibromatosis type 2. Understanding ASPHD2 function and modifications can provide insights into its role in these conditions and potential as a therapeutic target.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ASPHD2 Antibody (E-9) References:
- [Chromosome 22q11 deletion syndrome and its relevance for child and adolescent psychiatry. An overview of etiology, physical symptoms, aspects of child development and psychiatric disorders]. | Briegel, W. and Cohen, M. 2004. Z Kinder Jugendpsychiatr Psychother. 32: 107-15. PMID: 15181786
- Genes, brain development and psychiatric phenotypes in velo-cardio-facial syndrome. | Gothelf, D., et al. 2008. Dev Disabil Res Rev. 14: 59-68. PMID: 18636637
- Association of the PIK4CA schizophrenia-susceptibility gene in adults with the 22q11.2 deletion syndrome. | Vorstman, JA., et al. 2009. Am J Med Genet B Neuropsychiatr Genet. 150B: 430-3. PMID: 18646052
- Array analysis and molecular studies of INI1 in an infant with deletion 22q13 (Phelan-McDermid syndrome) and atypical teratoid/rhabdoid tumor. | Sathyamoorthi, S., et al. 2009. Am J Med Genet A. 149A: 1067-9. PMID: 19334084
- Neurofibromatosis 2 [Bilateral acoustic neurofibromatosis, central neurofibromatosis, NF2, neurofibromatosis type II]. | Evans, DG. 2009. Genet Med. 11: 599-610. PMID: 19652604
- Molecular cytogenetic characterization of variant Philadelphia translocations in chronic myeloid leukemia: genesis and deletion of derivative chromosome 9. | Bennour, A., et al. 2009. Cancer Genet Cytogenet. 194: 30-7. PMID: 19737651
- Philadelphia chromosome-positive acute lymphoblastic leukemia. | Ravandi, F. and Kebriaei, P. 2009. Hematol Oncol Clin North Am. 23: 1043-63, vi. PMID: 19825452
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ASPHD2 Antibody (E-9) | sc-390986 | 200 µg/ml | $322.00 | |||
ASPHD2 Antibody (E-9): m-IgG Fc BP-HRP Bundle | sc-527658 | 200 µg Ab; 10 µg BP | $361.00 | |||
ASPHD2 Antibody (E-9): m-IgG1 BP-HRP Bundle | sc-533031 | 200 µg Ab; 20 µg BP | $361.00 | |||
ASPHD2 Antibody (E-9) AC | sc-390986 AC | 500 µg/ml, 25% agarose | $424.00 | |||
ASPHD2 Antibody (E-9) HRP | sc-390986 HRP | 200 µg/ml | $322.00 | |||
ASPHD2 Antibody (E-9) FITC | sc-390986 FITC | 200 µg/ml | $336.00 | |||
ASPHD2 Antibody (E-9) PE | sc-390986 PE | 200 µg/ml | $349.00 | |||
ASPHD2 Antibody (E-9) Alexa Fluor® 488 | sc-390986 AF488 | 200 µg/ml | $364.00 | |||
ASPHD2 Antibody (E-9) Alexa Fluor® 546 | sc-390986 AF546 | 200 µg/ml | $364.00 | |||
ASPHD2 Antibody (E-9) Alexa Fluor® 594 | sc-390986 AF594 | 200 µg/ml | $364.00 | |||
ASPHD2 Antibody (E-9) Alexa Fluor® 647 | sc-390986 AF647 | 200 µg/ml | $364.00 | |||
ASPHD2 Antibody (E-9) Alexa Fluor® 680 | sc-390986 AF680 | 200 µg/ml | $364.00 | |||
ASPHD2 Antibody (E-9) Alexa Fluor® 790 | sc-390986 AF790 | 200 µg/ml | $364.00 | |||
ASPHD2 (E-9) Neutralizing Peptide | sc-390986 P | 100 µg/0.5 ml | $69.00 |