ASNSD1 Antibody (A-10): sc-398765

ASNSD1 Antibody (A-10) is a mouse monoclonal IgG2a antibody that detects ASNSD1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ASNSD1, also known as HCV NS3-transactivated protein 1 or NS3TP1, is a 643 amino acid protein characterized by one asparagine synthetase domain and a glutamine amidotransferase type-2 domain, which play crucial roles in amino acid metabolism and cellular stress responses. ASNSD1 is involved in asparagine synthesis, an amino acid vital for protein synthesis and cellular signaling. Dysregulation of ASNSD1 has been implicated in various diseases, highlighting ASNSD1′s potential as a therapeutic target. The gene encoding ASNSD1 is located on human chromosome 2, which resulted from the fusion of two ancestral chromosomes. This evolutionary perspective adds an intriguing layer to ASNSD1 research, as understanding genetic context may provide insights into functional roles and cellular interactions. ASNSD1 (A-10) antibody serves as an essential tool for researchers investigating this protein′s biological significance in various physiological and pathological contexts.

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ASNSD1 Antibody (A-10) References:

1. Hemizygous deletion of COL3A1, COL5A2, and MSTN causes a complex phenotype with aortic dissection: a lesson for and from true haploinsufficiency.  |  Meienberg, J., et al. 2010. Eur J Hum Genet. 18: 1315-21. PMID: 20648054
2. Upstream ORF-Encoded ASDURF Is a Novel Prefoldin-like Subunit of the PAQosome.  |  Cloutier, P., et al. 2020. J Proteome Res. 19: 18-27. PMID: 31738558
3. Genetic variants modulate gene expression statin response in human lymphoblastoid cell lines.  |  Theusch, E., et al. 2020. BMC Genomics. 21: 555. PMID: 32787775
4. Histopathology is required to identify and characterize myopathies in high-throughput phenotype screening of genetically engineered mice.  |  Vogel, P., et al. 2021. Vet Pathol. 58: 1158-1171. PMID: 34269122
5. High-Throughput Screening of Mouse Gene Knockouts Identifies Established and Novel High Body Fat Phenotypes.  |  Powell, DR., et al. 2021. Diabetes Metab Syndr Obes. 14: 3753-3785. PMID: 34483672
6. Identification and validation in a novel quantification system of the glutamine metabolism patterns for the prediction of prognosis and therapy response in hepatocellular carcinoma.  |  Jin, S., et al. 2022. J Gastrointest Oncol. 13: 2505-2521. PMID: 36388696
7. Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma.  |  Hofman, DA., et al. 2023. bioRxiv.. PMID: 37205492
8. Potential of PAQosome as a therapeutic target for hepatic fibrosis.  |  Shi, L., et al. 2024. J Gastroenterol Hepatol. 39: 381-391. PMID: 38016755
9. Glutamine metabolism-related genes and immunotherapy in nonspecific orbital inflammation were validated using bioinformatics and machine learning.  |  Wu, Z., et al. 2024. BMC Genomics. 25: 71. PMID: 38233749
10. Alzheimer's disease: an integrative bioinformatics and machine learning analysis reveals glutamine metabolism-associated gene biomarkers.  |  Xing, N., et al. 2025. BMC Pharmacol Toxicol. 26: 19. PMID: 39875978

The preferred ASNSD1 antibody is ASNSD1 Antibody (C-7): sc-374190.