ARP Antibody (B-3): sc-515906
- ARP Antibody (B-3) is a mouse monoclonal IgG1 κ ARP antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 90-108 within an internal region of ARP of human origin
- ARP Antibody (B-3) is recommended for detection of ARP of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-ARP Antibody (B-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgGκ BP-HRP is the preferred secondary detection reagent for ARP Antibody (B-3) for WB applications. This reagent is now offered in a bundle with ARP Antibody (B-3) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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SEE ALSO...
ARP Antibody (B-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects ARP protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ARP antibody (B-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The gene encoding arginine-rich protein (ARP), also known as ARMET, is highly conserved across species and is located on human chromosome 3p21. ARP protein plays a crucial role in cellular processes, although specific function remains to be fully elucidated. ARP has been implicated in various malignancies, including primary head and neck, non-small-cell lung, renal cell, breast, and prostate cancers, with mutations in ARP gene being a point of interest in cancer research. While earlier studies suggested that variations in the triplet AGG repeat around codon 50 might contribute to malignancy, more recent investigations have indicated no significant differences in this variation between normal and cancer patient populations. Research has discovered that ARP protein features a smaller N-terminal region that excludes the arginine-rich domain, with codon 50 serving as the actual start codon for ARP protein. This finding highlights the complexity of ARP protein′s structure and potential implications in understanding cancer biology and therapeutic targets.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ARP Antibody (B-3) References:
- Polymorphic variation of the ARP gene on 3p21 in Japanese esophageal cancer patients. | Tanaka, H., et al. 2000. Oncol Rep. 7: 591-3. PMID: 10767373
- A gene from human chromosomal band 3p21.1 encodes a highly conserved arginine-rich protein and is mutated in renal cell carcinomas. | Shridhar, V., et al. 1996. Oncogene. 12: 1931-9. PMID: 8649854
- Mutations in the arginine-rich protein gene (ARP) in pancreatic cancer. | Shridhar, V., et al. 1997. Oncogene. 14: 2213-6. PMID: 9174057
- Normal polymorphism in the incomplete trinucleotide repeat of the arginine-rich protein gene. | Evron, E., et al. 1997. Cancer Res. 57: 2888-9. PMID: 9230196
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ARP Antibody (B-3) | sc-515906 | 200 µg/ml | $322.00 | |||
ARP Antibody (B-3): m-IgGκ BP-HRP Bundle | sc-525278 | 200 µg Ab, 40 µg BP | $361.00 | |||
ARP Antibody (B-3) AC | sc-515906 AC | 500 µg/ml, 25% agarose | $424.00 | |||
ARP Antibody (B-3) HRP | sc-515906 HRP | 200 µg/ml | $322.00 | |||
ARP Antibody (B-3) FITC | sc-515906 FITC | 200 µg/ml | $336.00 | |||
ARP Antibody (B-3) PE | sc-515906 PE | 200 µg/ml | $349.00 | |||
ARP Antibody (B-3) Alexa Fluor® 488 | sc-515906 AF488 | 200 µg/ml | $364.00 | |||
ARP Antibody (B-3) Alexa Fluor® 546 | sc-515906 AF546 | 200 µg/ml | $364.00 | |||
ARP Antibody (B-3) Alexa Fluor® 594 | sc-515906 AF594 | 200 µg/ml | $364.00 | |||
ARP Antibody (B-3) Alexa Fluor® 647 | sc-515906 AF647 | 200 µg/ml | $364.00 | |||
ARP Antibody (B-3) Alexa Fluor® 680 | sc-515906 AF680 | 200 µg/ml | $364.00 | |||
ARP Antibody (B-3) Alexa Fluor® 790 | sc-515906 AF790 | 200 µg/ml | $364.00 |