ARL13B Antibody (6F11): sc-293467
- ARL13B Antibody (6F11) is a mouse monoclonal IgG2a κ provided at 100 µg/ml
- raised against a partial recombinant protein mapping within amino acids 329-428 of ARL13B of human origin
- recommended for detection of ARL13B of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for ARL13B Antibody (6F11). This work is in progress.
ARL13B Antibody (6F11) is a mouse monoclonal IgG2a antibody that detects ARL13B in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). ARL13B, also known as ADP-ribosylation factor-like 13B or JBTS8, is a 428 amino acid protein that plays a crucial role in cilia formation, which is essential for various cellular processes, including signaling pathways and cellular motility. The proper functioning of cilia is vital for maintaining homeostasis in tissues and organs, and defects in ARL13B can lead to Joubert syndrome, a rare genetic disorder characterized by severe neurological impairments due to an underdeveloped cerebellum and brain stem. This highlights the importance of ARL13B not only in cilia biogenesis but also in the broader context of neurodevelopmental health. Anti-ARL13B antibody (6F11) is an invaluable tool for researchers studying the molecular mechanisms underlying cilia-related diseases and the intricate pathways influenced by this critical protein.
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ARL13B Antibody (6F11) References:
- Domain architecture of the atypical Arf-family GTPase Arl13b involved in cilia formation. | Hori, Y., et al. 2008. Biochem Biophys Res Commun. 373: 119-24. PMID: 18554500
- Arl13b regulates endocytic recycling traffic. | Barral, DC., et al. 2012. Proc Natl Acad Sci U S A. 109: 21354-9. PMID: 23223633
- Arl13b and the non-muscle myosin heavy chain IIA are required for circular dorsal ruffle formation and cell migration. | Casalou, C., et al. 2014. J Cell Sci. 127: 2709-22. PMID: 24777479
- Arl13b and the exocyst interact synergistically in ciliogenesis. | Seixas, C., et al. 2016. Mol Biol Cell. 27: 308-20. PMID: 26582389
- Arl13b Promotes Gastric Tumorigenesis by Regulating Smo Trafficking and Activation of the Hedgehog Signaling Pathway. | Shao, J., et al. 2017. Cancer Res. 77: 4000-4013. PMID: 28611043
- The Joubert syndrome protein ARL13B binds tubulin to maintain uniform distribution of proteins along the ciliary membrane. | Revenkova, E., et al. 2018. J Cell Sci. 131: PMID: 29592971
- Interaction of INPP5E with ARL13B is essential for its ciliary membrane retention but dispensable for its ciliary entry. | Qiu, H., et al. 2021. Biol Open. 10: PMID: 33372066
- ARL3 and ARL13B GTPases participate in distinct steps of INPP5E targeting to the ciliary membrane. | Fujisawa, S., et al. 2021. Biol Open. 10: PMID: 34447983
- ARL13B promotes angiogenesis and glioma growth by activating VEGFA-VEGFR2 signaling. | Chen, L., et al. 2023. Neuro Oncol. 25: 871-885. PMID: 36322624
- Increasing Ciliary ARL13B Expression Drives Active and Inhibitor-Resistant Smoothened and GLI into Glioma Primary Cilia. | Shi, P., et al. 2023. Cells. 12: PMID: 37830570
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ARL13B Antibody (6F11) | sc-293467 | 100 µg/ml | $316.00 |