ARID3A Antibody (4D6): sc-101030

ARID3A Antibody (4D6) is a mouse monoclonal IgG1 antibody that detects ARID3A in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). ARID3A plays a crucial role in the regulation of gene expression during development, particularly in differentiating cells of the gut and salivary glands, making ARID3A essential for proper cellular function and tissue development. ARID3A is a member of a unique family of transcriptional activators, characterized by an A/T-rich DNA-binding (ARID) domain, which allows ARID3A to bind to specific DNA sequences and regulate the transcription of target genes. ARID3A′s ability to form tetramers is significant for function, as this structural feature enhances stability and interaction with other proteins in the transcriptional machinery. The gene encoding ARID3A is linked to Peutz-Jeghers syndrome, an autosomal-dominant disorder that increases the risk of various neoplasms, including gastrointestinal cancer, highlighting ARID3A′s importance in both development and disease. E2FBP1, which shares identity with ARID3A in its carboxy terminal region, further illustrates the functional complexity, as E2FBP1 regulates cell proliferation by interacting with the transcription factor E2F-1, although E2FBP1 lacks the DNA binding and transactivation capabilities of ARID3A. With diverse roles in cellular processes and implications in disease, anti-ARID3A antibody (4D6) is an invaluable tool for researchers studying gene regulation and related pathologies.

The preferred ARID3A antibody is ARID3A Antibody (A-4): sc-398367.