ARHGEF16 Antibody (G-10): sc-377104
- ARHGEF16 Antibody (G-10) is a mouse monoclonal IgG1 κ ARHGEF16 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 683-708 at the C-terminus of ARHGEF16 of human origin
- ARHGEF16 Antibody (G-10) is recommended for detection of ARHGEF16 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
- Anti-ARHGEF16 Antibody (G-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for ARHGEF16 Antibody (G-10) for WB applications. These reagents are now offered in bundles with ARHGEF16 Antibody (G-10) (see ordering information below).
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ARHGEF16 Antibody (G-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects ARHGEF16 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ARHGEF16 (G-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ARHGEF16 protein, also known as Rho guanine exchange factor 16, plays a crucial role in regulating Rho GTPases, which are essential for numerous cellular processes such as cytoskeletal dynamics, cell migration, and cell cycle progression. Located primarily in the cytoplasm, ARHGEF16 interacts with Rho family GTPases to facilitate the exchange of GDP for GTP, thereby activating these signaling molecules in response to external stimuli. This activation is vital for the proper functioning of G-protein coupled receptors, which mediate various physiological responses. ARHGEF16 consists of 709 amino acids and features a distinctive structure that includes a DBL-homology domain, a pleckstrin homology domain, and an SH3 domain, each contributing to regulatory functions. ARHGEF16 exists in two alternatively spliced isoforms and is encoded by a gene located on human chromosome 1, which is significant as this chromosome contains a substantial portion of the human genome, encompassing over 3,000 genes and spanning 260 million base pairs.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ARHGEF16 Antibody (G-10) References:
- Structural basis for the selective activation of Rho GTPases by Dbl exchange factors. | Snyder, JT., et al. 2002. Nat Struct Biol. 9: 468-75. PMID: 12006984
- EphA4-mediated Rho activation via Vsm-RhoGEF expressed specifically in vascular smooth muscle cells. | Ogita, H., et al. 2003. Circ Res. 93: 23-31. PMID: 12775584
- Expression of RHOGTPase regulators in human myometrium. | O'Brien, M., et al. 2008. Reprod Biol Endocrinol. 6: 1. PMID: 18190708
- Common variants on 1p36 and 1q42 are associated with cutaneous basal cell carcinoma but not with melanoma or pigmentation traits. | Stacey, SN., et al. 2008. Nat Genet. 40: 1313-8. PMID: 18849993
- Involvement of betaPIX in angiotensin II-induced migration of vascular smooth muscle cells. | Shin, EY., et al. 2009. Exp Mol Med. 41: 387-96. PMID: 19322025
- Regulation of immature dendritic cell migration by RhoA guanine nucleotide exchange factor Arhgef5. | Wang, Z., et al. 2009. J Biol Chem. 284: 28599-606. PMID: 19713215
- Expression cDNA cloning of a novel oncogene with sequence similarity to regulators of small GTP-binding proteins. | Chan, AM., et al. 1994. Oncogene. 9: 1057-63. PMID: 8134109
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ARHGEF16 Antibody (G-10) | sc-377104 | 200 µg/ml | $322.00 | |||
ARHGEF16 Antibody (G-10): m-IgG Fc BP-HRP Bundle | sc-527581 | 200 µg Ab; 10 µg BP | $361.00 | |||
ARHGEF16 Antibody (G-10): m-IgG1 BP-HRP Bundle | sc-532954 | 200 µg Ab; 20 µg BP | $361.00 | |||
ARHGEF16 Antibody (G-10) AC | sc-377104 AC | 500 µg/ml, 25% agarose | $424.00 | |||
ARHGEF16 Antibody (G-10) HRP | sc-377104 HRP | 200 µg/ml | $322.00 | |||
ARHGEF16 Antibody (G-10) FITC | sc-377104 FITC | 200 µg/ml | $336.00 | |||
ARHGEF16 Antibody (G-10) PE | sc-377104 PE | 200 µg/ml | $349.00 | |||
ARHGEF16 Antibody (G-10) Alexa Fluor® 488 | sc-377104 AF488 | 200 µg/ml | $364.00 | |||
ARHGEF16 Antibody (G-10) Alexa Fluor® 546 | sc-377104 AF546 | 200 µg/ml | $364.00 | |||
ARHGEF16 Antibody (G-10) Alexa Fluor® 594 | sc-377104 AF594 | 200 µg/ml | $364.00 | |||
ARHGEF16 Antibody (G-10) Alexa Fluor® 647 | sc-377104 AF647 | 200 µg/ml | $364.00 | |||
ARHGEF16 Antibody (G-10) Alexa Fluor® 680 | sc-377104 AF680 | 200 µg/ml | $364.00 | |||
ARHGEF16 Antibody (G-10) Alexa Fluor® 790 | sc-377104 AF790 | 200 µg/ml | $364.00 | |||
ARHGEF16 (G-10) Neutralizing Peptide | sc-377104 P | 100 µg/0.5 ml | $69.00 |