ARHGAP39 Antibody (D-6): sc-515231
- ARHGAP39 Antibody (D-6) is a mouse monoclonal IgG1 κ ARHGAP39 antibody provided at 200 µg/ml
- raised against amino acids 426-674 mapping within an internal region of ARHGAP39 of human origin
- ARHGAP39 Antibody (D-6) is recommended for detection of ARHGAP39 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-ARHGAP39 Antibody (D-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG1 BP-HRP is the preferred secondary detection reagent for ARHGAP39 Antibody (D-6) for WB applications. This reagent is now offered in a bundle with ARHGAP39 Antibody (D-6) (see ordering information below).
ARHGAP39 Antibody (D-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects ARHGAP39 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-ARHGAP39 antibody (D-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ARHGAP39, also known as KIAA1688, plays a crucial role in cellular signaling by acting as a GTPase-activating protein (GAP) that accelerates the hydrolysis of GTP to GDP on Ras-related proteins, thereby downregulating their active forms. This function is vital for regulating the Rho family of GTPases, which are involved in various cellular processes such as cytoskeletal dynamics, cell migration, and proliferation. ARHGAP39 consists of 1,083 amino acids and features one MyTH4 domain, one Rho-GAP domain, and two WW domains, which are essential for interaction with other proteins and cellular components. The gene encoding ARHGAP39 is located on human chromosome 8, a region associated with several diseases, including schizophrenia and various malignancies, highlighting the importance of understanding ARHGAP39 function and regulation in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ARHGAP39 Antibody (D-6) References:
- Chromosomes 8 and 10 workshop. | Wildenauer, DB. and Schwab, SG. 1999. Am J Med Genet. 88: 239-43. PMID: 10374738
- Preferential expression of an intact WRN gene in Werner syndrome cell lines in which a normal chromosome 8 has been introduced. | Kashino, G., et al. 2001. Biochem Biophys Res Commun. 289: 111-5. PMID: 11708785
- Cytogenetic mapping of a novel locus for type II Waardenburg syndrome. | Selicorni, A., et al. 2002. Hum Genet. 110: 64-7. PMID: 11810298
- Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q. | McQueen, MB., et al. 2005. Am J Hum Genet. 77: 582-95. PMID: 16175504
- DNA sequence and analysis of human chromosome 8. | Nusbaum, C., et al. 2006. Nature. 439: 331-5. PMID: 16421571
- Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer. | Agrelo, R., et al. 2006. Proc Natl Acad Sci U S A. 103: 8822-7. PMID: 16723399
- Non-Hodgkin's lymphomas with Burkitt-like cells are associated with c-Myc amplification and poor prognosis. | Mossafa, H., et al. 2006. Leuk Lymphoma. 47: 1885-93. PMID: 17065002
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ARHGAP39 Antibody (D-6) | sc-515231 | 200 µg/ml | $322.00 | |||
ARHGAP39 Antibody (D-6): m-IgG1 BP-HRP Bundle | sc-531803 | 200 µg Ab; 20 µg BP | $361.00 | |||
ARHGAP39 Antibody (D-6) AC | sc-515231 AC | 500 µg/ml, 25% agarose | $424.00 | |||
ARHGAP39 Antibody (D-6) HRP | sc-515231 HRP | 200 µg/ml | $322.00 | |||
ARHGAP39 Antibody (D-6) FITC | sc-515231 FITC | 200 µg/ml | $336.00 | |||
ARHGAP39 Antibody (D-6) PE | sc-515231 PE | 200 µg/ml | $349.00 | |||
ARHGAP39 Antibody (D-6) Alexa Fluor® 488 | sc-515231 AF488 | 200 µg/ml | $364.00 | |||
ARHGAP39 Antibody (D-6) Alexa Fluor® 546 | sc-515231 AF546 | 200 µg/ml | $364.00 | |||
ARHGAP39 Antibody (D-6) Alexa Fluor® 594 | sc-515231 AF594 | 200 µg/ml | $364.00 | |||
ARHGAP39 Antibody (D-6) Alexa Fluor® 647 | sc-515231 AF647 | 200 µg/ml | $364.00 | |||
ARHGAP39 Antibody (D-6) Alexa Fluor® 680 | sc-515231 AF680 | 200 µg/ml | $364.00 | |||
ARHGAP39 Antibody (D-6) Alexa Fluor® 790 | sc-515231 AF790 | 200 µg/ml | $364.00 |