ARG-Vasopressin Antibody (VAS 10-2-2): sc-73504

ARG-Vasopressin Antibody (VAS 10-2-2) is a mouse monoclonal IgG2b antibody that detects ARG-Vasopressin protein of human origin by enzyme-linked immunosorbent assay (ELISA). Anti-ARG-Vasopressin antibody (VAS 10-2-2) is available as a non-conjugated monoclonal isotype antibody. ARG-Vasopressin plays a crucial role as an antidiuretic hormone, primarily involved in regulating body fluid homeostasis, which is vital for maintaining blood pressure and overall fluid balance in the body. ARG-Vasopressin is synthesized in the hypothalamus and stored in the posterior pituitary gland, where release into the bloodstream occurs in response to changes in osmotic pressure. Precise regulation of ARG-Vasopressin is essential, as excessive secretion can lead to increased mean arterial pressure and systemic vascular resistance, potentially resulting in cardiovascular complications. ARG-Vasopressin has been implicated in various pathological conditions, including certain cancers, where ARG-Vasopressin may function as an autocrine growth factor, promoting tumor growth through pathways such as ERK1/2 activation. ARG-Vasopressin presence at both cell surface and in secreted forms in cancer cell lines like Skbr3 and Mcf7 highlights significance in cancer biology. Additionally, antidiuretic action of ARG-Vasopressin is mediated through Vasopressin V2 receptor, which is critical for water retention and can influence conditions such as migraines by promoting antinociception. These multifaceted roles of ARG-Vasopressin underscore importance as a therapeutic target in both acute and chronic heart failure, making ARG-Vasopressin (VAS 10-2-2) monoclonal antibody an invaluable tool for research and clinical applications.

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ARG-Vasopressin Antibody (VAS 10-2-2) References:

1. Arrestin effects on internalization of vasopressin receptors.  |  Bowen-Pidgeon, D., et al. 2001. Mol Pharmacol. 59: 1395-401. PMID: 11353798
2. Arg-vasopressin increases proliferation of human osteoblast-like cells and decreases production of interleukin-6 and macrophage colony-stimulating factor.  |  Lagumdzija, A., et al. 2004. Regul Pept. 121: 41-8. PMID: 15256272
3. Arginine vasopressin in 316 patients with advanced vasodilatory shock.  |  Luckner, G., et al. 2005. Crit Care Med. 33: 2659-66. PMID: 16276194
4. Vasopressin antagonism in heart failure.  |  Goldsmith, SR. and Gheorghiade, M. 2005. J Am Coll Cardiol. 46: 1785-91. PMID: 16286160
5. Recurrent syncope, hypotension, asthma, and migraine with aura: role of metoclopramide.  |  Gupta, VK. 2005. Headache. 45: 1413-6. PMID: 16324177
6. An N-terminal variant of Trpv1 channel is required for osmosensory transduction.  |  Sharif Naeini, R., et al. 2006. Nat Neurosci. 9: 93-8. PMID: 16327782
7. Local overexpression of V1a-vasopressin receptor enhances regeneration in tumor necrosis factor-induced muscle atrophy.  |  Costa, A., et al. 2014. Biomed Res Int. 2014: 235426. PMID: 24971321
8. Increase in cytosolic calcium and phosphoinositide metabolism induced by angiotensin II and [Arg]vasopressin in vascular smooth muscle cells.  |  Nabika, T., et al. 1985. J Biol Chem. 260: 4661-70. PMID: 2985562
9. Vasopressin stimulation of mouse 3T3 cell growth.  |  Rozengurt, E., et al. 1979. Proc Natl Acad Sci U S A. 76: 1284-7. PMID: 312501
10. Circadian rhythm of Arg-vasopressin contents in the suprachiasmatic nucleus in relation to corticosterone.  |  Isobe, Y. and Isobe, M. 1998. Brain Res. 800: 78-85. PMID: 9685591
11. Provasopressin expression by breast cancer cells: implications for growth and novel treatment strategies.  |  Keegan, BP., et al. 2006. Breast Cancer Res Treat. 95: 265-77. PMID: 16331351
12. Investigation of mechanism of desmopressin binding in vasopressin V2 receptor versus vasopressin V1a and oxytocin receptors: molecular dynamics simulation of the agonist-bound state in the membrane-aqueous system.  |  Slusarz, MJ., et al. 2006. Biopolymers. 81: 321-38. PMID: 16333859

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ARG-Vasopressin Antibody (VAS 10-2-2) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-ARG-Vasopressin Antibody (VAS 10-2-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ARG-Vasopressin Antibody (VAS 10-2-2) Specifications

Alternate Product Name: ARG-Vasopressin

Product Clone Name: VAS 10-2-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b

Amino Acids:

Epitope Target: ARG-Vasopressin

Epitope Species: human

Product Reactivity/Detection: ARG-Vasopressin

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: ELISA

Vialing Information: Each vial contains 100 µg IgG_2b in 1.0 ml of TBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for ARG-Vasopressin Antibody (VAS 10-2-2): N/A