Arc Antibody (C-7): sc-17839
- Arc Antibody (C-7) is a mouse monoclonal IgG2a κ Arc antibody, cited in 165 publications, provided at 200 µg/ml
- raised against amino acids 1-300 of Arc of human origin
- Arc Antibody (C-7) is recommended for detection of ARC of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-Arc Antibody (C-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for Arc Antibody (C-7) for WB applications. These reagents are now offered in bundles with Arc Antibody (C-7) (see ordering information below).
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Arc Antibody (C-7) is a mouse monoclonal IgG2a kappa light chain antibody designed to target the Arc protein, also known as activity-regulated cytoskeleton-associated protein or Arg3.1, by recognizing amino acids 1-300 of the human Arc protein. Anti-Arc antibody (C-7) can detect Arc across multiple species, including mouse, rat, and human, and is suitable for various applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). The Arc protein is a critical immediate early gene involved in synaptic plasticity, learning, and memory, playing a pivotal role in regulating the cytoskeleton and modulating synaptic strength in response to neuronal activity. Arc expression is rapidly induced by growth factors and neurotransmitters, facilitating long-term cellular responses and neuroplastic changes essential for cognitive functions. Arc is predominantly localized in neuronal cell bodies and dendrites within key brain regions like the hippocampus, amygdala, hypothalamus, striatum, and cortex, where Arc interacts with F-Actin and other actin-associated proteins to influence dendritic spine morphology and synaptic efficacy. Arc (C-7) antibody is available in both non-conjugated form and various conjugated variants, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing versatile tools for diverse experimental setups. Additionally, Arc expression has been linked to responses to stimuli such as cocaine, underscoring Arc′s role in activity-dependent gene regulation and potential implications in neurological disorders. Arc monoclonal antibody (C-7) enables researchers to thoroughly investigate the dynamic regulation of Arc protein in various biological contexts, thereby advancing our understanding of neural plasticity and related pathologies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Arc Antibody (C-7) References:
- Stimulation of neuronal acetylcholine receptors induces rapid gene transcription. | Greenberg, ME., et al. 1986. Science. 234: 80-3. PMID: 3749894
- A critical period for macromolecular synthesis in long-term heterosynaptic facilitation in Aplysia. | Montarolo, PG., et al. 1986. Science. 234: 1249-54. PMID: 3775383
- Activation of arc, a putative 'effector' immediate early gene, by cocaine in rat brain. | Fosnaugh, JS., et al. 1995. J Neurochem. 64: 2377-80. PMID: 7722525
- Arc, a growth factor and activity-regulated gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites. | Lyford, GL., et al. 1995. Neuron. 14: 433-45. PMID: 7857651
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Arc Antibody (C-7) | sc-17839 | 200 µg/ml | $316.00 | |||
Arc Antibody (C-7): m-IgG Fc BP-HRP Bundle | sc-525495 | 200 µg Ab; 10 µg BP | $354.00 | |||
Arc Antibody (C-7): m-IgG2a BP-HRP Bundle | sc-546288 | 200 µg Ab; 10 µg BP | $354.00 | |||
Arc Antibody (C-7) AC | sc-17839 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Arc Antibody (C-7) HRP | sc-17839 HRP | 200 µg/ml | $316.00 | |||
Arc Antibody (C-7) FITC | sc-17839 FITC | 200 µg/ml | $330.00 | |||
Arc Antibody (C-7) PE | sc-17839 PE | 200 µg/ml | $343.00 | |||
Arc Antibody (C-7) Alexa Fluor® 488 | sc-17839 AF488 | 200 µg/ml | $357.00 | |||
Arc Antibody (C-7) Alexa Fluor® 546 | sc-17839 AF546 | 200 µg/ml | $357.00 | |||
Arc Antibody (C-7) Alexa Fluor® 594 | sc-17839 AF594 | 200 µg/ml | $357.00 | |||
Arc Antibody (C-7) Alexa Fluor® 647 | sc-17839 AF647 | 200 µg/ml | $357.00 | |||
Arc Antibody (C-7) Alexa Fluor® 680 | sc-17839 AF680 | 200 µg/ml | $357.00 | |||
Arc Antibody (C-7) Alexa Fluor® 790 | sc-17839 AF790 | 200 µg/ml | $357.00 |