Aprataxin Antibody (B-3): sc-365849

Aprataxin Antibody (B-3) is a mouse monoclonal IgG2b antibody that detects Aprataxin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Aprataxin is a crucial nuclear protein located in both the nucleoplasm and nucleolus, playing a vital role in DNA single-strand break repair. Aprataxin is a member of the histidine triad (HIT) superfamily and mediates protein-protein interactions with other molecules involved in cellular response to DNA damage. The structure of Aprataxin includes three conserved domains: an N-terminal forkhead-associated (FHA) domain that facilitates these interactions, a HIT domain that shares similarities with Hint, and a C-terminal zinc finger domain that contributes to stability and function. Mutations in the APTX gene, which encodes Aprataxin, can lead to protein destabilization and are associated with a rare neurological disorder known as ataxia-oculomotor apraxia, characterized by abnormal head and eye movements. These mutations typically affect the HIT domain or result in truncation before the zinc finger, underscoring Aprataxin′s structural integrity for DNA repair and cellular health. Anti-Aprataxin antibody (B-3) serves as an invaluable tool for researchers studying DNA damage response mechanisms and Aprataxin′s implications in neurological disorders.

The preferred Aprataxin antibody is Aprataxin Antibody (B-12): sc-374108.