APPBP1 Antibody (20): sc-135839
- APPBP1 Antibody (20) is a mouse monoclonal IgG2a provided at 50 µg/0.5 ml
- raised against amino acids 348-464 of APPBP1 of human origin
- recommended for detection of APPBP1 of mouse, rat, human and canine origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for APPBP1 Antibody (20). This work is in progress.
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APPBP1 Antibody (20) is a mouse monoclonal IgG2a antibody that detects APPBP1 in mouse, rat, human, and canine samples through western blotting (WB) and immunoprecipitation (IP) applications. APPBP1, also known as NAE1 or HPP1, is a crucial member of the ubiquitin-activating E1 family, predominantly expressed in fetal tissues and throughout the brain in adults. APPBP1 is primarily located at the cell membrane and functions as the regulatory subunit in a heterodimeric complex with UBA3, which is essential for the activation of NEDD8, a ubiquitin-like protein that plays a significant role in various cellular processes, including signal transduction, cell proliferation, and development. The interaction between APPBP1 and UBA3 is vital for the regulation of the cell cycle, particularly at the S/M checkpoint, where APPBP1 inhibits the transition into the S phase while promoting entry into the M phase. This regulatory function underscores APPBP1′s importance in maintaining proper cell cycle progression and cellular homeostasis, making APPBP1 a key target for studies related to cell growth and division. Anti-APPBP1 antibody (20) is an invaluable tool for researchers investigating the intricate mechanisms of cell cycle regulation and the broader implications of NEDD8 signaling pathways in various biological contexts.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
APPBP1 Antibody (20) | sc-135839 | 50 µg/0.5 ml | $322.00 |