apoL1 Antibody (A-3): sc-390440
- apoL1 Antibody (A-3) is a mouse monoclonal IgG1 κ apoL1 antibody, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 201-285 mapping within an internal region of apoL1 of human origin
- apoL1 Antibody (A-3) is recommended for detection of apoL1 of human origin by WB, IP, IF and ELISA
- Anti-apoL1 Antibody (A-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for apoL1 Antibody (A-3) for WB applications. These reagents are now offered in bundles with apoL1 Antibody (A-3) (see ordering information below).
apoL1 Antibody (A-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects the apoL1 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). apoL1 (A-3) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. apoL1 plays a crucial role in lipid metabolism and is involved in the transport of lipids within the bloodstream, which is essential for maintaining cellular homeostasis and preventing lipid-related diseases. Specifically, apoL1 interacts with high-density lipoproteins (HDL), facilitating the removal of excess cholesterol from peripheral tissues and transporting cholesterol to the liver for excretion. This function is particularly important for cardiovascular health, as dysregulation of lipid transport can lead to atherosclerosis and other cardiovascular diseases. The apoL gene family, which includes apoL1, is located on chromosome 22q12.1-13.1 and is characterized by TATA-less promoters and potential sterol regulatory elements, indicating a complex regulation linked to lipid metabolism pathways. With significant roles in lipid transport and metabolism, apoL1 remains a vital protein for researchers studying cardiovascular health and related disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
apoL1 Antibody (A-3) References:
- Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes. | Horrevoets, AJ., et al. 1999. Blood. 93: 3418-31. PMID: 10233894
- Apolipoprotein L gene family: tissue-specific expression, splicing, promoter regions; discovery of a new gene. | Duchateau, PN., et al. 2001. J Lipid Res. 42: 620-30. PMID: 11290834
- The human apolipoprotein L gene cluster: identification, classification, and sites of distribution. | Page, NM., et al. 2001. Genomics. 74: 71-8. PMID: 11374903
- The apolipoprotein L gene cluster has emerged recently in evolution and is expressed in human vascular tissue. | Monajemi, H., et al. 2002. Genomics. 79: 539-46. PMID: 11944986
- Apolipoprotein L-I is the trypanosome lytic factor of human serum. | Vanhamme, L., et al. 2003. Nature. 422: 83-7. PMID: 12621437
- Distribution of apolipoprotein L-I and trypanosome lytic activity among primate sera. | Poelvoorde, P., et al. 2004. Mol Biochem Parasitol. 134: 155-7. PMID: 14747153
- Apolipoprotein L-I is positively associated with hyperglycemia and plasma triglycerides in CAD patients with low HDL. | Albert, TS., et al. 2005. J Lipid Res. 46: 469-74. PMID: 15604524
- Apolipoprotein L, a new human high density lipoprotein apolipoprotein expressed by the pancreas. Identification, cloning, characterization, and plasma distribution of apolipoprotein L. | Duchateau, PN., et al. 1997. J Biol Chem. 272: 25576-82. PMID: 9325276
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
apoL1 Antibody (A-3) | sc-390440 | 200 µg/ml | $322.00 | |||
apoL1 Antibody (A-3): m-IgG Fc BP-HRP Bundle | sc-527631 | 200 µg Ab; 10 µg BP | $361.00 | |||
apoL1 Antibody (A-3): m-IgG1 BP-HRP Bundle | sc-533004 | 200 µg Ab; 20 µg BP | $361.00 | |||
apoL1 Antibody (A-3) AC | sc-390440 AC | 500 µg/ml, 25% agarose | $424.00 | |||
apoL1 Antibody (A-3) HRP | sc-390440 HRP | 200 µg/ml | $322.00 | |||
apoL1 Antibody (A-3) FITC | sc-390440 FITC | 200 µg/ml | $336.00 | |||
apoL1 Antibody (A-3) PE | sc-390440 PE | 200 µg/ml | $349.00 | |||
apoL1 Antibody (A-3) Alexa Fluor® 488 | sc-390440 AF488 | 200 µg/ml | $364.00 | |||
apoL1 Antibody (A-3) Alexa Fluor® 546 | sc-390440 AF546 | 200 µg/ml | $364.00 | |||
apoL1 Antibody (A-3) Alexa Fluor® 594 | sc-390440 AF594 | 200 µg/ml | $364.00 | |||
apoL1 Antibody (A-3) Alexa Fluor® 647 | sc-390440 AF647 | 200 µg/ml | $364.00 | |||
apoL1 Antibody (A-3) Alexa Fluor® 680 | sc-390440 AF680 | 200 µg/ml | $364.00 | |||
apoL1 Antibody (A-3) Alexa Fluor® 790 | sc-390440 AF790 | 200 µg/ml | $364.00 |