Apolipoprotein A I/APOA1 Antibody (A5.4): sc-13549

apoA-I Antibody (A5.4) is a mouse monoclonal IgG1 antibody that detects apolipoprotein A-I in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. ApoA-I is a crucial component of high-density lipoprotein (HDL) in plasma, consisting of a single chain of 243 amino acids that plays a vital role in cholesterol metabolism by promoting the efflux of cholesterol from peripheral tissues to the liver for excretion. This process is essential for maintaining lipid homeostasis and preventing atherosclerosis, a condition characterized by the buildup of fats, cholesterol, and other substances in and on the artery walls. Additionally, apoA-I serves as a cofactor for lecithin cholesterol acyltransferase (LCAT), an enzyme that catalyzes the formation of cholesteryl esters, further facilitating the transport and metabolism of lipids. The importance of apoA-I extends beyond its structural role; apoA-I is also involved in the regulation of plasma triglyceride levels and influences the activity of other apolipoproteins, making apoA-I a key player in cardiovascular health. With apoA-I′s ability to interact with various lipid molecules and enzymes, apoA-I is not only a marker for HDL but also a significant factor in understanding lipid-related diseases.

The preferred Apolipoprotein A I/APOA1 antibody is Apolipoprotein A I/APOA1 Antibody (B-10): sc-376818.