APEH Antibody (G-6): sc-376612

APEH Antibody (G-6) is a mouse monoclonal IgM antibody that detects APEH protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-APEH antibody (G-6) is available as the non-conjugated form. APEH, or Acyl-peptide hydrolase, is a 732 amino acid cytoplasmic protein that forms a homotetramer and plays a crucial role in the hydrolysis of N-terminal acetylated amino acids from small acetylated peptides. This enzymatic activity facilitates the recycling of amino acids and the regulation of protein turnover, which are essential processes for maintaining cellular homeostasis and responding to metabolic demands. The gene encoding human APEH is located on chromosome 3, a region often deleted in various cancers, including renal cell carcinoma and small cell lung carcinoma, indicating a potential role for APEH in tumorigenesis. Chromosome 3 encompasses approximately 214 million bases and contains over 1,100 genes, including key tumor suppressor genes such as RASSF1, which mediates apoptosis, HYAL1, which regulates cell migration, and SEMA3B, an angiogenesis suppressor. APEH′s functional implications in cellular processes underscore its importance in both normal physiology and disease states, making APEH (G-6) antibody a valuable tool for research in cancer biology and protein metabolism.

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APEH Antibody (G-6) References:

1. Structural investigations on human erythrocyte acylpeptide hydrolase by mass spectrometric procedures.  |  Scaloni, A., et al. 1999. J Protein Chem. 18: 349-60. PMID: 10395453
2. Acylpeptide hydrolase: inhibitors and some active site residues of the human enzyme.  |  Scaloni, A., et al. 1992. J Biol Chem. 267: 3811-8. PMID: 1740429
3. Inhibition mechanism of carbapenem antibiotics on acylpeptide hydrolase, a key enzyme in the interaction with valproic acid.  |  Suzuki, E., et al. 2011. Xenobiotica. 41: 958-63. PMID: 21770850
4. Acylpeptide hydrolase inhibition as targeted strategy to induce proteasomal down-regulation.  |  Palmieri, G., et al. 2011. PLoS One. 6: e25888. PMID: 22016782
5. Identification and characterisation of a novel acylpeptide hydrolase from Sulfolobus solfataricus: structural and functional insights.  |  Gogliettino, M., et al. 2012. PLoS One. 7: e37921. PMID: 22655081
6. A gene near the D3F15S2 site on 3p is expressed in normal human kidney but not or only at a severely reduced level in 11 of 15 primary renal cell carcinomas (RCC).  |  Erlandsson, R., et al. 1990. Oncogene. 5: 1207-11. PMID: 2392324
7. The DNF15S2 locus at 3p21 is transcribed in normal lung and small cell lung cancer.  |  Naylor, SL., et al. 1989. Genomics. 4: 355-61. PMID: 2565880
8. Computational study of the competitive binding of valproic acid glucuronide and carbapenem antibiotics to acylpeptide hydrolase.  |  Ishikawa, T., et al. 2017. Drug Metab Pharmacokinet. 32: 201-207. PMID: 28734645
9. Polymorphism of regulatory region of APEH gene (c.-521G>C, rs4855883) as a relevant predictive factor for radiotherapy induced oral mucositis and overall survival in head neck cancer patients.  |  Brzozowska, A., et al. 2018. Oncotarget. 9: 29644-29653. PMID: 30038710
10. Discovery of an Enzyme-Activated Fluorogenic Probe for In Vivo Profiling of Acylaminoacyl-Peptide Hydrolase.  |  Liu, SY., et al. 2025. Anal Chem. 97: 2204-2213. PMID: 39862163
11. Deletion mapping of chromosome 3p in human uterine cervical cancer.  |  Kohno, T., et al. 1993. Oncogene. 8: 1825-32. PMID: 8099726
12. The nucleotide sequence of human acylamino acid-releasing enzyme.  |  Mitta, M., et al. 1996. DNA Res. 3: 31-5. PMID: 8724851

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-APEH Antibody (G-6) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-APEH Antibody (G-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

APEH Antibody (G-6) Specifications

Alternate Product Name: APEH

Product Clone Name: G-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 23-59

Epitope Target: APEH

Epitope Species: human

Product Reactivity/Detection: APEH

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for APEH Antibody (G-6): P: Blocking Peptide