APEH Activators
APEH, short for Acylaminoacyl-Peptidase, also known as Acyl-peptide hydrolase, is a protein encoded by the APEH gene in humans. It is an enzyme that belongs to the prolyl oligopeptidase family, playing a critical role in protein degradation and turnover in cells.APEH is involved in the removal of N-acylated amino acids from blocked peptides, a crucial step in processing damaged or modified proteins for degradation. It is essential for the maintenance of protein homeostasis in cells, helping to stop the accumulation of potentially harmful, damaged proteins.
The APEH protein is ubiquitously expressed in various tissues, underscoring its fundamental role in cellular function. It is located in the cytoplasm but can also be secreted outside the cell, suggesting a potential role in extracellular processes as well.Alterations in APEH function have been associated with various diseases. For instance, mutations in the APEH gene have been linked with Spinocerebellar Ataxia, a neurodegenerative disorder characterized by loss of motor coordination. APEH has also been implicated in cancer progression. In some cancers, APEH overexpression has been associated with enhanced cancer cell survival and resistance to certain anti-cancer drugs.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bestatin | 58970-76-6 | sc-202975 | 10 mg | $131.00 | 19 | |
A protease inhibitor that might affect peptidase activity, potentially impacting APEH. | ||||||
E-64 | 66701-25-5 | sc-201276 sc-201276A sc-201276B | 5 mg 25 mg 250 mg | $281.00 $947.00 $1574.00 | 14 | |
An irreversible cysteine protease inhibitor, might indirectly affect APEH's role in peptide degradation. | ||||||
Leupeptin hemisulfate | 103476-89-7 | sc-295358 sc-295358A sc-295358D sc-295358E sc-295358B sc-295358C | 5 mg 25 mg 50 mg 100 mg 500 mg 10 mg | $73.00 $148.00 $316.00 $499.00 $1427.00 $101.00 | 19 | |
A protease inhibitor, could impact proteolytic processes relevant to APEH. | ||||||
Aprotinin | 9087-70-1 | sc-3595 sc-3595A sc-3595B | 10 mg 100 mg 1 g | $112.00 $408.00 $3000.00 | 51 | |
A protease inhibitor, might indirectly affect APEH by modulating protein degradation. | ||||||
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | $188.00 $575.00 | 60 | |
Another proteasome inhibitor, potentially affecting protein turnover and indirectly APEH activity. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $91.00 $267.00 | 13 | |
A proteasome and calpain inhibitor, possibly influencing APEH activity indirectly. | ||||||
Z-VAD-FMK | 187389-52-2 | sc-3067 | 500 µg | $75.00 | 256 | |
A broad-spectrum caspase inhibitor, could affect proteolytic processes related to APEH. | ||||||
Chymostatin | 9076-44-2 | sc-202541 sc-202541A sc-202541B sc-202541C sc-202541D | 5 mg 10 mg 25 mg 50 mg 100 mg | $156.00 $260.00 $640.00 $1186.00 $2270.00 | 3 | |
Inhibits chymotrypsin-like proteases, potentially influencing proteolytic pathways involving APEH. | ||||||