AP-4ε Antibody (32): sc-135835

AP-4ε Antibody (32) is a mouse monoclonal IgG1 kappa light chain antibody that detects AP-4 epsilon (AP-4ε) by western blotting (WB) and immunoprecipitation (IP). Anti-AP-4ε antibody (32) is available as a non-conjugated monoclonal isotype antibody. AP-4ε is a crucial component of the adapter-related protein complex 4, which plays a significant role in intracellular transport by mediating cargo incorporation into transport vesicles. AP-4ε functions within a protein complex essential for sorting and trafficking proteins within cells, particularly in the trans-Golgi network and endosomal pathways. The AP-4 complex consists of four subunits: AP-4b, AP-4e, AP-4m, and AP-4s, interacting with various cargo proteins through specific motifs in their cytoplasmic tails. AP-4ε contributes to basolateral protein sorting in epithelial cells and participates in glutamate receptor d2 (Grid2) trafficking in the brain, highlighting AP-4ε′s importance in neuronal function and signaling. AP-4ε shows widespread expression in the brain, with localization in Golgi-like structures within neuronal cell bodies and dendrites, underscoring AP-4ε′s vital role in maintaining cellular homeostasis and communication.

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AP-4ε Antibody (32) References:

1. AP-4, a novel protein complex related to clathrin adaptors.  |  Dell'Angelica, EC., et al. 1999. J Biol Chem. 274: 7278-85. PMID: 10066790
2. Characterization of a fourth adaptor-related protein complex.  |  Hirst, J., et al. 1999. Mol Biol Cell. 10: 2787-802. PMID: 10436028
3. Signal-binding specificity of the mu4 subunit of the adaptor protein complex AP-4.  |  Aguilar, RC., et al. 2001. J Biol Chem. 276: 13145-52. PMID: 11139587
4. Functional and physical interactions of the adaptor protein complex AP-4 with ADP-ribosylation factors (ARFs).  |  Boehm, M., et al. 2001. EMBO J. 20: 6265-76. PMID: 11707398
5. AP-4 binds basolateral signals and participates in basolateral sorting in epithelial MDCK cells.  |  Simmen, T., et al. 2002. Nat Cell Biol. 4: 154-9. PMID: 11802162
6. Adaptor protein complex-4 (AP-4) is expressed in the central nervous system neurons and interacts with glutamate receptor delta2.  |  Yap, CC., et al. 2003. Mol Cell Neurosci. 24: 283-95. PMID: 14572453
7. The adaptor protein AP-4 as a component of the clathrin coat machinery: a morphological study.  |  Barois, N. and Bakke, O. 2005. Biochem J. 385: 503-10. PMID: 15377281

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-AP-4ε Antibody (32) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-AP-4ε Antibody (32) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

AP-4ε Antibody (32) Specifications

Alternate Product Name: AP-4ε

Product Clone Name: 32

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 685-793

Epitope Target: AP-4ε

Epitope Species: human

Product Reactivity/Detection: AP-4ε

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for AP-4ε Antibody (32): N/A