AP-2γ Antibody (6E4/4): sc-12762

AP-2γ Antibody (6E4/4) is a mouse monoclonal IgG1 kappa light chain antibody that detects AP-2 gamma protein of mouse, rat, and human origin through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry (IHC). AP-2γ (6E4/4) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase, phycoerythrin, fluorescein isothiocyanate, and multiple Alexa Fluor® conjugates. AP-2 gamma protein, also known as TFAP2C, plays a crucial role in gene regulation by binding to specific DNA sequences, thereby initiating transcription of target genes. This function is particularly important in developmental processes and cellular differentiation, as AP-2γ is involved in the regulation of genes associated with the development of ectodermal tissues and the expression of the proto-oncogene c-ErbB-2, which is overexpressed in a significant percentage of breast cancers. AP-2γ interacts with other members of the AP-2 transcription factor family, including AP-2α and AP-2β, forming complexes that modulate gene expression in response to various signaling pathways. AP-2γ regulation of estrogen receptor expression further underscores AP-2γ importance in hormonal signaling and cancer biology, making AP-2γ a valuable tool for researchers studying these critical pathways.

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AP-2γ Antibody (6E4/4) References:

1. AP-2gamma induces p21 expression, arrests cell cycle, and inhibits the tumor growth of human carcinoma cells.  |  Li, H., et al. 2006. Neoplasia. 8: 568-77. PMID: 16867219
2. Ovarian dysgerminomas are characterised by frequent KIT mutations and abundant expression of pluripotency markers.  |  Hoei-Hansen, CE., et al. 2007. Mol Cancer. 6: 12. PMID: 17274819
3. Activator protein-2 in carcinogenesis with a special reference to breast cancer--a mini review.  |  Pellikainen, JM. and Kosma, VM. 2007. Int J Cancer. 120: 2061-7. PMID: 17330235
4. Cloning and expression of AP-2, a cell-type-specific transcription factor that activates inducible enhancer elements.  |  Williams, T., et al. 1988. Genes Dev. 2: 1557-69. PMID: 3063603
5. The biological characteristics of transcription factors AP-2α and AP-2γ and their importance in various types of cancers.  |  Kołat, D., et al. 2019. Biosci Rep. 39: PMID: 30824562
6. AP-2γ Is Required for Maintenance of Multipotent Mammary Stem Cells.  |  Gu, VW., et al. 2021. Stem Cell Reports. 16: 106-119. PMID: 33382976
7. TRIM37 Augments AP-2γ Transcriptional Activity and Cellular Localization via K63-linked Ubiquitination to Drive Breast Cancer Progression.  |  Cui, G., et al. 2022. Int J Biol Sci. 18: 4316-4328. PMID: 35864973
8. Cloning and characterization of a second AP-2 transcription factor: AP-2 beta.  |  Moser, M., et al. 1995. Development. 121: 2779-88. PMID: 7555706
9. An alternatively spliced mRNA from the AP-2 gene encodes a negative regulator of transcriptional activation by AP-2.  |  Buettner, R., et al. 1993. Mol Cell Biol. 13: 4174-85. PMID: 8321221
10. Chromosomal mapping of the human and mouse homologues of two new members of the AP-2 family of transcription factors.  |  Williamson, JA., et al. 1996. Genomics. 35: 262-4. PMID: 8661133
11. A family of AP-2 proteins regulates c-erbB-2 expression in mammary carcinoma.  |  Bosher, JM., et al. 1996. Oncogene. 13: 1701-7. PMID: 8895516
12. Identification of ERF-1 as a member of the AP2 transcription factor family.  |  McPherson, LA., et al. 1997. Proc Natl Acad Sci U S A. 94: 4342-7. PMID: 9113991

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-AP-2γ Antibody (6E4/4) has 146 citations in a variety of scientific publications.

Primary antibodies like Anti-AP-2γ Antibody (6E4/4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

AP-2γ Antibody (6E4/4) Specifications

Alternate Product Name: Transcription Factor AP-2 Gamma

Product Clone Name: 6E4/4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: AP-2γ

Epitope Species: human

Product Reactivity/Detection: AP-2γ

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 146 citations in various scientific publications

Available Conjugates/Forms for AP-2γ Antibody (6E4/4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, X: TransCruz Reagent