AP-2β Antibody (A-1): sc-166441

AP-2β Antibody (A-1) is a mouse monoclonal IgG1 antibody that detects AP-2β in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). AP-2β, a splice variant of the AP-2α transcription factor, plays a crucial role in regulating gene expression by binding to specific DNA sequences, thereby influencing various biological processes, including cell differentiation and proliferation. AP-2β (A-1) antibody helps researchers study AP-2β′s involvement in modulating AP-2α activity, which maintains transcriptional regulation balance within the AP-2 complex. This complex is significant in cancer biology, as AP-2β can inhibit AP-2α activity, potentially impacting oncogene expression such as c-ErbB-2, which is overexpressed in many breast cancers. AP-2β′s ability to interact with other transcription factors and involvement in ectodermal-derived tissue development highlights its importance in both normal physiological processes and disease states. Deleterious mutations in AP-2β have been associated with various developmental disorders, underscoring the necessity of studying this protein in both health and disease. With broad species reactivity and versatile applications, anti-AP-2β antibody (A-1) serves as an invaluable tool for researchers investigating AP-2β′s intricate roles in cellular functions and disease mechanisms.

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AP-2β Antibody (A-1) References:

1. AP-2α and AP-2β regulate dorsal interneuron specification in the spinal cord.  |  Xu, X., et al. 2017. Neuroscience. 340: 232-242. PMID: 27984181
2. AP-2β inhibits hepatocellular carcinoma invasion and metastasis through Slug and Snail to suppress epithelial-mesenchymal transition.  |  Yang, L., et al. 2018. Theranostics. 8: 3707-3721. PMID: 30026878
3. AP-2β/KCTD1 Control Distal Nephron Differentiation and Protect against Renal Fibrosis.  |  Marneros, AG. 2020. Dev Cell. 54: 348-366.e5. PMID: 32553120
4. Transcription factor AP-2beta in development, differentiation and tumorigenesis.  |  Raap, M., et al. 2021. Int J Cancer. 149: 1221-1227. PMID: 33720400
5. AP-2α and AP-2β cooperatively function in the craniofacial surface ectoderm to regulate chromatin and gene expression dynamics during facial development.  |  Van Otterloo, E., et al. 2022. Elife. 11: PMID: 35333176
6. Transcription factors AP-2α and AP-2β regulate distinct segments of the distal nephron in the mammalian kidney.  |  Lamontagne, JO., et al. 2022. Nat Commun. 13: 2226. PMID: 35468900
7. The regulatory role of AP-2β in monoaminergic neurotransmitter systems: insights on its signalling pathway, linked disorders and theragnostic potential.  |  Al-Sabri, MH., et al. 2022. Cell Biosci. 12: 151. PMID: 36076256
8. Ap-2β regulates cranial osteogenic potential via the activation of Wnt/β-catenin signaling pathway.  |  Hu, S., et al. 2023. Dev Biol. 501: 81-91. PMID: 37355029
9. AP-2α/AP-2β Transcription Factors Are Key Regulators of Epidermal Homeostasis.  |  Zhang, H., et al. 2024. J Invest Dermatol. 144: 1505-1521.e12. PMID: 38237728
10. Autophagy initiation triggers p150Glued-AP-2β interaction on the lysosomes and facilitates their transport.  |  Tempes, A., et al. 2024. Cell Mol Life Sci. 81: 218. PMID: 38758395

The preferred AP-2β antibody is AP-2β Antibody (C-6): sc-390119.