ANP32A Antibody (A-182): sc-100767
- ANP32A Antibody (A-182) is a mouse monoclonal IgG1 κ ANP32A antibody, cited in 5 publications, provided at 100 µg/ml
- raised against recombinant ANP32A of human origin
- recommended for detection of ANP32A of human origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for ANP32A Antibody (A-182). This work is in progress.
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ANP32A Antibody (A-182) is a mouse monoclonal IgG1 kappa light chain antibody that detects ANP32A protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-ANP32A antibody (A-182) is available as a non-conjugated format. ANP32A, also known as Inhibitor 1 of protein phosphatase 2A (PP2A), plays a crucial role in regulating cellular processes by inhibiting PP2A activity, a major serine/threonine phosphatase in mammals. This inhibition is significant because PP2A is involved in various signaling pathways that control cell growth, division, and apoptosis, making ANP32A a key player in maintaining cellular homeostasis. ANP32A is primarily localized in both cytoplasm and nucleus, which is important for regulatory functions, as ANP32A can influence both cytoplasmic and nuclear signaling pathways. Notably, ANP32A interaction with PP2A is noncompetitive, allowing selective inhibition of PP2A without affecting the activity of other phosphatases such as PP1, PP2B, and PP2C. This specificity is vital for precise regulation of cellular signaling, particularly in contexts such as cancer, where aberrant PP2A activity can lead to uncontrolled cell proliferation.
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ANP32A Antibody (A-182) References:
- Expression of I2PP2A, an inhibitor of protein phosphatase 2A, induces c-Jun and AP-1 activity. | Al-Murrani, SW., et al. 1999. Biochem J. 341 (Pt 2): 293-8. PMID: 10393085
- Autophosphorylation-activated protein kinase inactivates the protein tyrosine phosphatase activity of protein phosphatase 2A. | Damuni, Z., et al. 1994. FEBS Lett. 352: 311-4. PMID: 7523189
- Purification and characterization of two potent heat-stable protein inhibitors of protein phosphatase 2A from bovine kidney. | Li, M., et al. 1995. Biochemistry. 34: 1988-96. PMID: 7531497
- Autophosphorylation-activated protein kinase phosphorylates and inactivates protein phosphatase 2A. | Guo, H. and Damuni, Z. 1993. Proc Natl Acad Sci U S A. 90: 2500-4. PMID: 7681598
- The myeloid leukemia-associated protein SET is a potent inhibitor of protein phosphatase 2A. | Li, M., et al. 1996. J Biol Chem. 271: 11059-62. PMID: 8626647
- Molecular identification of I1PP2A, a novel potent heat-stable inhibitor protein of protein phosphatase 2A. | Li, M., et al. 1996. Biochemistry. 35: 6998-7002. PMID: 8679524
- I1PP2A and I2PP2A. Two potent protein phosphatase 2A-specific inhibitor proteins. | Li, M. and Damuni, Z. 1998. Methods Mol Biol. 93: 59-66. PMID: 9664527
- Expression of SET, an inhibitor of protein phosphatase 2A, in renal development and Wilms' tumor. | Carlson, SG., et al. 1998. J Am Soc Nephrol. 9: 1873-80. PMID: 9773788
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ANP32A Antibody (A-182) | sc-100767 | 100 µg/ml | $333.00 |