Annexin VIII Antibody (C-11): sc-514498
- Annexin VIII Antibody (C-11) is a mouse monoclonal IgG2a κ Annexin VIII antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 120-154 within an internal region of Annexin VIII of human origin
- Annexin VIII Antibody (C-11) is recommended for detection of Annexin VIII of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-Annexin VIII Antibody (C-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for Annexin VIII Antibody (C-11) for WB applications. These reagents are now offered in bundles with Annexin VIII Antibody (C-11) (see ordering information below).
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Annexin VIII Antibody (C-11) is a mouse monoclonal IgG2a kappa light chain antibody designed to detect Annexin VIII, also known as ANXA8, Annexin A8, or Vascular Anticoagulant Beta antibody, across multiple applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Annexin VIII monoclonal antibody (C-11) targets a specific epitope between amino acids 120-154 within an internal region of human Annexin VIII, ensuring selective and reliable binding. Annexin VIII is a member of the annexin family of calcium-binding proteins, characterized by a conserved core domain that facilitates phospholipid binding in a calcium-dependent manner. Within cells, Annexin VIII primarily localizes to the cytoplasm and participates in membrane-related processes such as endocytosis, exocytosis, and vesicle trafficking. Precise localization maintains cellular homeostasis and facilitates communication between cellular compartments, playing a vital role in processes like ion flux regulation, cellular adhesion, and signal transduction. Annexin VIII interacts with specific proteins, including calmodulin and protein kinase C (PKC), which are essential for various signaling pathways and cellular responses to environmental stimuli. These interactions underscore Annexin VIII′s importance in cellular differentiation, particularly in hematopoietic cells, and elevated expression in acute promyelocytic leukemia (APL) cells highlights potential as a biomarker for certain malignancies. Anti-Annexin VIII antibody (C-11) exhibits strong reactivity with Annexin VIII from mouse, rat, and human origins, providing versatility for comparative studies across different model organisms. Available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, Annexin VIII (C-11) antibody offers flexible options to meet diverse experimental needs.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Annexin VIII Antibody (C-11) References:
- Specific expression of the annexin VIII gene in acute promyelocytic leukemia. | Chang, KS., et al. 1992. Blood. 79: 1802-10. PMID: 1313714
- Copy number amplification and SP1-activated lncRNA MELTF-AS1 regulates tumorigenesis by driving phase separation of YBX1 to activate ANXA8 in non-small cell lung cancer. | Lu, X., et al. 2022. Oncogene. 41: 3222-3238. PMID: 35508543
- The effect of TFAP2A/ANXA8 axis on ferroptosis of cervical squamous cell carcinoma (CESC) in vitro. | Sheng, Y., et al. 2024. Cytotechnology. 76: 403-414. PMID: 38933875
- Inhibitory effect of annexin V on protein kinase C activity in mesangial cell lysates. | Rothhut, B., et al. 1995. Eur J Biochem. 232: 865-72. PMID: 7588728
- Annexin IV inhibits calmodulin-dependent protein kinase II-activated chloride conductance. A novel mechanism for ion channel regulation. | Chan, HC., et al. 1994. J Biol Chem. 269: 32464-8. PMID: 7798247
- Differential tissue expression of Annexin VIII in human. | Reutelingsperger, CP., et al. 1994. FEBS Lett. 349: 120-4. PMID: 8045287
- Expression of the annexin VIII gene in acute promyelocytic leukemia. | Liu, JH., et al. 1994. Leuk Lymphoma. 13: 381-6. PMID: 8069182
- Structural evolution of the annexin supergene family. | Smith, PD. and Moss, SE. 1994. Trends Genet. 10: 241-6. PMID: 8091504
- Expression and modulation of annexin VIII in human leukemia-lymphoma cell lines. | Hu, ZB., et al. 1993. Leuk Res. 17: 949-57. PMID: 8231235
- Calcium-dependent binding of S100C to the N-terminal domain of annexin I. | Mailliard, WS., et al. 1996. J Biol Chem. 271: 719-25. PMID: 8557678
- Structural and functional characterisation of the voltage sensor in the ion channel human annexin V. | Liemann, S., et al. 1996. J Mol Biol. 258: 555-61. PMID: 8636991
- The high-resolution crystal structure of human annexin III shows subtle differences with annexin V. | Favier-Perron, B., et al. 1996. Biochemistry. 35: 1740-4. PMID: 8639653
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Annexin VIII Antibody (C-11) | sc-514498 | 200 µg/ml | $316.00 | |||
Annexin VIII Antibody (C-11): m-IgG Fc BP-HRP Bundle | sc-526374 | 200 µg Ab; 10 µg BP | $354.00 | |||
Annexin VIII Antibody (C-11): m-IgG2a BP-HRP Bundle | sc-546611 | 200 µg Ab; 10 µg BP | $354.00 | |||
Annexin VIII Antibody (C-11) AC | sc-514498 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Annexin VIII Antibody (C-11) HRP | sc-514498 HRP | 200 µg/ml | $316.00 | |||
Annexin VIII Antibody (C-11) FITC | sc-514498 FITC | 200 µg/ml | $330.00 | |||
Annexin VIII Antibody (C-11) PE | sc-514498 PE | 200 µg/ml | $343.00 | |||
Annexin VIII Antibody (C-11) Alexa Fluor® 488 | sc-514498 AF488 | 200 µg/ml | $357.00 | |||
Annexin VIII Antibody (C-11) Alexa Fluor® 546 | sc-514498 AF546 | 200 µg/ml | $357.00 | |||
Annexin VIII Antibody (C-11) Alexa Fluor® 594 | sc-514498 AF594 | 200 µg/ml | $357.00 | |||
Annexin VIII Antibody (C-11) Alexa Fluor® 647 | sc-514498 AF647 | 200 µg/ml | $357.00 | |||
Annexin VIII Antibody (C-11) Alexa Fluor® 680 | sc-514498 AF680 | 200 µg/ml | $357.00 | |||
Annexin VIII Antibody (C-11) Alexa Fluor® 790 | sc-514498 AF790 | 200 µg/ml | $357.00 | |||
Annexin VIII (C-11) Neutralizing Peptide | sc-514498 P | 100 µg/0.5 ml | $68.00 |