Annexin VII Antibody (5): sc-135832
- Annexin VII Antibody (5) is a mouse monoclonal IgG1 provided at 50 µg/0.5 ml
- raised against amino acids 34-159 of Annexin VII of human origin
- recommended for detection of Annexin VII of human origin by WB, IP and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Annexin VII Antibody (5). This work is in progress.
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Annexin VII Antibody (5) is a mouse monoclonal IgG1 antibody that detects Annexin VII in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Annexin VII, also known as synexin, plays a crucial role in cellular processes by binding to phospholipids in a calcium-dependent manner, which is essential for maintaining membrane integrity and facilitating membrane fusion events. Anti-Annexin VII antibody (5) recognizes protein predominantly located at the plasma membrane in normal muscle tissue, where Annexin VII contributes to the regulation of ion transport and cellular signaling. However, in pathological conditions such as Duchenne′s muscular dystrophy, Annexin VII is aberrantly released into the cytoplasm and subsequently into the extracellular space, indicating a potential role in disease progression and muscle degeneration. Annexin VII′s ability to interact with other annexins and proteins further underscores its importance in cellular dynamics and highlights potential as a biomarker for muscle-related disorders. Anti-Annexin VII antibody (5) serves as an invaluable tool for researchers investigating the functional implications of Annexin VII in both healthy and diseased states.
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Annexin VII Antibody (5) References:
- Annexin VII and annexin XI are tyrosine phosphorylated in peroxovanadate-treated dogs and in platelet-derived growth factor-treated rat vascular smooth muscle cells. | Furge, LL., et al. 1999. J Biol Chem. 274: 33504-9. PMID: 10559235
- Low in vivo levels of human anx7 (annexin vii) gene expression are due to endogenous inhibitory promoter sequences. | Srivastava, M. and Pollard, HB. 2000. Cell Biol Int. 24: 475-81. PMID: 10875895
- Immunolocalization of synexin (annexin VII) in adrenal chromaffin granules and chromaffin cells: evidence for a dynamic role in the secretory process. | Kuijpers, GA., et al. 1992. Cell Tissue Res. 269: 323-30. PMID: 1423500
- Properties and modification of recombinant human synexin (annexin VII). | Burns, AL., et al. 1991. Ann N Y Acad Sci. 635: 450-1. PMID: 1660250
- The W105G and W99G sorcin mutants demonstrate the role of the D helix in the Ca(2+)-dependent interaction with annexin VII and the cardiac ryanodine receptor. | Colotti, G., et al. 2006. Biochemistry. 45: 12519-29. PMID: 17029407
- Molecular basis for the impaired function of the natural F112L sorcin mutant: X-ray crystal structure, calcium affinity, and interaction with annexin VII and the ryanodine receptor. | Franceschini, S., et al. 2008. FASEB J. 22: 295-306. PMID: 17699613
- Sequence and expression of annexin VII of Dictyostelium discoideum. | Greenwood, M. and Tsang, A. 1991. Biochim Biophys Acta. 1088: 429-32. PMID: 1826615
- Divergent structure of the human synexin (annexin VII) gene and assignment to chromosome 10. | Shirvan, A., et al. 1994. Biochemistry. 33: 6888-901. PMID: 7515686
- Annexin VII relocalization as a result of dystrophin deficiency. | Selbert, S., et al. 1996. Exp Cell Res. 222: 199-208. PMID: 8549664
- Synexin (annexin VII) hypothesis for Ca2+/GTP-regulated exocytosis. | Pollard, HB., et al. 1998. Adv Pharmacol. 42: 81-7. PMID: 9327852
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Annexin VII Antibody (5) | sc-135832 | 50 µg/0.5 ml | $316.00 |