Annexin-2/ANXA2 Antibody (3D5): sc-47696

Annexin II Antibody (3D5) is a mouse monoclonal IgG2a kappa light chain antibody raised against whole native Annexin proteins from human bone tissues, capable of detecting Annexin II of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Annexin II, also known as Annexin A2, Calpactin II, Chromobindin-8, Lipocortin II, or p36, is a calcium-dependent phospholipid-binding protein that plays a crucial role in various cellular processes. Predominantly located in the cytoplasm and on the cell surface, Annexin II mediates membrane-related events like endocytosis, exocytosis, and cellular adhesion. Surface-expressed Annexin II acts as a receptor for plasminogen and tissue plasminogen activator (tPA), facilitating plasmin generation and playing a key role in fibrinolysis and blood coagulation. Annexin II can exist as a monomer or form a heterotetramer complex with S100A10 (p11), known as calpactin I, which is involved in signal transduction pathways. Annexin II is also a substrate for protein kinase C (PKC) and Src family kinases, indicating involvement in phosphorylation-dependent signaling mechanisms. Anti-Annexin II antibody (3D5) enables researchers to study Annexin II involvement in pathological conditions such as cancer progression, inflammation, and coagulation disorders. Annexin II (3D5) antibody is available in both unconjugated and multiple conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and various Alexa Fluor® conjugates, providing versatility for different experimental applications.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Annexin-2/ANXA2 Antibody (3D5) has 16 citations in a variety of scientific publications.

Primary antibodies like Anti-Annexin-2/ANXA2 Antibody (3D5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Annexin-2/ANXA2 Antibody (3D5) Specifications

Alternate Product Name: Annexin II

Product Clone Name: 3D5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids:

Epitope Target: Annexin II

Epitope Species: human

Product Reactivity/Detection: Annexin II

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 16 citations in various scientific publications

Available Conjugates/Forms for Annexin-2/ANXA2 Antibody (3D5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred Annexin-2/ANXA2 antibody is Annexin-2/ANXA2 Antibody (C-10): sc-28385.