Annexin II Activators
Annexin II (ANXA2) activators represent a heterogeneous class of chemical compounds designed to either directly enhance the functional activity of ANXA2 or influence signaling events leading to its activation. ANXA2 holds a pivotal role in cellular adhesion, migration, and inflammatory responses, and the identified compounds strategically target specific pathways or processes, collectively contributing to the heightened activation of ANXA2. One subgroup of activators, including aspirin, curcumin, and caffeic acid, operates by activating ANXA2 through the inhibition of NF-kB signaling. This mechanism suggests an anti-inflammatory role for ANXA2, as these compounds modulate cellular inflammatory responses. Phorbol esters, exemplified by Phorbol 12-Myristate 13-Acetate and staurosporine, activate ANXA2 through PKC signaling, providing valuable insights into the regulatory role of PKC pathways in cellular adhesion and migration processes associated with ANXA2.
Polyphenolic compounds, such as epigallocatechin gallate (EGCG) and genistein, contribute to the enhancement of ANXA2 function by modulating cellular redox status and inhibiting tyrosine kinases, respectively. These compounds hint at the involvement of ANXA2 in cellular responses to oxidative stress and intracellular signaling events. Another set of activators, including heparin and nafamostat, activates ANXA2 by influencing fibrinolysis, thereby suggesting a regulatory role for ANXA2 in coagulation and tissue remodeling processes. The diverse mechanisms deployed by these chemical compounds to activate ANXA2 collectively illuminate the multifaceted functions of ANXA2 in various cellular processes. These insights provide a foundation for further exploration into the intricate regulatory networks involving ANXA2 and its implications in health and disease.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Aspirin | 50-78-2 | sc-202471 sc-202471A | 5 g 50 g | $20.00 $41.00 | 4 | |
Aspirin activates Annexin II through inhibition of NF-kB signaling, promoting anti-inflammatory effects. Annexin II plays a role in regulating cell adhesion and migration, suggesting aspirin's potential in modulating cellular processes. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Activates Annexin II via PKC signaling, influencing cellular adhesion and membrane dynamics. Phorbol esters induce intracellular pathways that enhance Annexin II function, suggesting their role in modulating cell surface interactions. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG enhances Annexin II function by modulating cellular redox status and inhibiting NF-kB signaling. This polyphenol contributes to anti-inflammatory effects, implicating Annexin II in the cellular response to oxidative stress. | ||||||
Heparin | 9005-49-6 | sc-507344 | 25 mg | $117.00 | 1 | |
Activates Annexin II by facilitating its interaction with plasminogen, influencing fibrinolysis. Heparin's impact on Annexin II-mediated processes provides insights into its potential role in modulating coagulation and tissue remodeling. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Modulates Annexin II activity through PKC inhibition, influencing cell adhesion and migration. Staurosporine's impact on Annexin II-related processes provides insights into its potential role in regulating cellular dynamics and membrane interactions. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Activates Annexin II via inhibition of tyrosine kinases, impacting cellular signaling pathways. Genistein's modulation of Annexin II function suggests its potential in regulating intracellular signaling and cellular responses mediated by Annexin II. | ||||||
NDGA (Nordihydroguaiaretic acid) | 500-38-9 | sc-200487 sc-200487A sc-200487B | 1 g 5 g 25 g | $107.00 $376.00 $2147.00 | 3 | |
NDGA enhances Annexin II function through modulation of cellular redox status, influencing inflammatory processes. The impact of NDGA on Annexin II suggests its potential in regulating cellular responses to oxidative stress and inflammation. | ||||||
Nafamostat mesylate | 82956-11-4 | sc-201307 sc-201307A | 10 mg 50 mg | $80.00 $300.00 | 4 | |
Activates Annexin II by inhibiting plasmin generation, influencing fibrinolysis. Nafamostat's impact on Annexin II-mediated processes provides insights into its potential role in modulating coagulation and tissue remodeling. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
Modulates Annexin II activity via PKC inhibition, impacting cellular adhesion and migration. Bisindolylmaleimide I's impact on Annexin II-related processes provides insights into its potential role in regulating cellular dynamics and membrane interactions. | ||||||
Caffeic Acid | 331-39-5 | sc-200499 sc-200499A | 1 g 5 g | $31.00 $61.00 | 1 | |
Enhances Annexin II function by modulating cellular redox status and inhibiting NF-kB signaling. Caffeic acid's impact on Annexin II suggests its potential in regulating inflammatory responses and cellular processes mediated by Annexin II. | ||||||