Annexin II Inhibitors
Annexin II inhibitors belong to a specialized class of compounds designed to selectively target annexin II, a calcium-binding protein known for its involvement in various cellular processes, including membrane organization, vesicle trafficking, and cell signaling. Annexin II is implicated in facilitating the interaction between the plasma membrane and the cytoskeleton, contributing to the dynamic changes in cell shape and movement. Moreover, annexin II plays a role in processes such as endocytosis and exocytosis, regulating the transport of molecules across cellular membranes. Annexin II inhibitors are meticulously crafted molecules engineered to interfere with the function or interactions of annexin II, disrupting its role in cellular membrane dynamics and signaling pathways.
Chemically, annexin II inhibitors are developed to selectively bind to specific regions or functional domains of the annexin II protein, aiming to obstruct its calcium-binding sites or interactions with other cellular components. The molecular structure of these inhibitors is intricately designed to fit into the binding sites or active regions of annexin II, preventing its association with membranes or disrupting its interactions with cytoskeletal proteins.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
5-FU can inhibit DNA synthesis. By affecting rapidly dividing cells, it may specifically down-regulate Annexin II expression in certain cell types. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone can modulate various cellular processes and may down-regulate Annexin II expression in specific cells under particular conditions. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Tretinoin may down-regulate Annexin II expression by modulating cell differentiation processes in particular cellular contexts. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR signaling, which can influence protein synthesis. This might lead to the down-regulation of Annexin II. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Etoposide, by affecting DNA replication and transcription, might specifically down-regulate Annexin II in certain contexts. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib, a proteasome inhibitor, can affect protein turnover, which might influence the stability and down-regulation of Annexin II. | ||||||
Tamoxifen | 10540-29-1 | sc-208414 | 2.5 g | $256.00 | 18 | |
Tamoxifen might down-regulate Annexin II expression by modulating estrogen receptor signaling under specific conditions. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
TSA, by affecting chromatin structure, might lead to the transcriptional down-regulation of Annexin II in certain cell types. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
Hydroxyurea might suppress Annexin II expression by inhibiting DNA synthesis in rapidly dividing cells. | ||||||
Mifepristone | 84371-65-3 | sc-203134 | 100 mg | $60.00 | 17 | |
Mifepristone, a glucocorticoid receptor antagonist, could potentially down-regulate Annexin II in specific cellular contexts. | ||||||