Annexin I Antibody (74/3): sc-65872

Annexin I Antibody (74/3) is a mouse monoclonal IgG1 kappa light chain antibody designed to detect Annexin I, also known as ANXA1 and Lipocortin I. Annexin I monoclonal antibody (74/3) is raised against AG1523 fibroblasts of human origin, ensuring precise recognition of Annexin I in applications such as western blotting (WB) and immunoprecipitation (IP). Annexin I is a crucial member of the annexin family of calcium-binding proteins, characterized by a conserved core domain that facilitates calcium-dependent phospholipid binding and a unique N-terminal region that imparts binding specificity. Structurally, Annexin I undergoes post-translational modifications, including phosphorylation, which are essential for regulating anti-inflammatory functions and interactions with other cellular proteins. These modifications play a significant role in modulating Annexin I′s ability to inhibit phospholipase A2 (cPLA2), thereby controlling the production of pro-inflammatory eicosanoids and mediating cellular response to glucocorticoids. Additionally, Annexin I is involved in key cellular processes such as endocytosis, exocytosis, and cellular adhesion, which are vital for maintaining cellular homeostasis and facilitating communication between cells. Precise detection of Annexin I enables researchers to investigate roles in various physiological and pathological contexts, including inflammation, cancer, and tissue repair. By targeting both native and modified forms of Annexin I, anti-Annexin I antibody (74/3) provides valuable insights into regulatory mechanisms and impact on cellular function. Annexin I (74/3) antibody is an indispensable tool for scientists aiming to elucidate complex roles of Annexin I in health and disease, making this antibody a vital addition to any research laboratory focused on cellular biology and inflammatory pathways.

The preferred Annexin I antibody is Annexin I Antibody (EH17a): sc-12740.