ANKRD50 Antibody (E-12): sc-390588

ANKRD50 Antibody (E-12) is a mouse monoclonal IgG2a kappa light chain antibody that detects ANKRD50 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-ANKRD50 antibody (E-12) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ANKRD50 protein consists of 1,429 amino acids and contains nineteen ankyrin repeats, playing a crucial role in cellular signaling and protein-protein interactions, particularly in the context of the cytoskeleton. ANKRD50 functions as a phosphoprotein vital for maintaining cellular integrity and facilitating communication between the cell membrane and cytoskeleton, essential for processes such as cell shape maintenance, motility, and intracellular transport. Mutations in ankyrin genes, including ANKRD50, can lead to severe genetic disorders, highlighting ANKRD50′s importance in human health. ANKRD50 gene is conserved across various species, including chimpanzees, dogs, cows, and zebrafish, and is located on human chromosome 4q28.1, a region associated with several genetic conditions. Understanding ANKRD50′s role in cellular processes can provide insights into potential implications in diseases linked to cytoskeletal dysfunction and genetic disorders.

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ANKRD50 Antibody (E-12) References:

1. Selective neuronal degeneration in Huntington's disease.  |  Cowan, CM. and Raymond, LA. 2006. Curr Top Dev Biol. 75: 25-71. PMID: 16984809
2. Evc is a positive mediator of Ihh-regulated bone growth that localises at the base of chondrocyte cilia.  |  Ruiz-Perez, VL., et al. 2007. Development. 134: 2903-12. PMID: 17660199
3. Identification of type 2 diabetes genes in Mexican Americans through genome-wide association studies.  |  Hayes, MG., et al. 2007. Diabetes. 56: 3033-44. PMID: 17846124
4. Metabolic phenotype of methylmalonic acidemia in mice and humans: the role of skeletal muscle.  |  Chandler, RJ., et al. 2007. BMC Med Genet. 8: 64. PMID: 17937813
5. Snail1 is a transcriptional effector of FGFR3 signaling during chondrogenesis and achondroplasias.  |  de Frutos, CA., et al. 2007. Dev Cell. 13: 872-83. PMID: 18061568
6. Towards a pathway definition of Parkinson's disease: a complex disorder with links to cancer, diabetes and inflammation.  |  Moran, LB. and Graeber, MB. 2008. Neurogenetics. 9: 1-13. PMID: 18196299
7. [Effect of leukapheresis on gene expression profiles of donor's peripheral blood mononuclear cells].  |  Shin, JW., et al. 2008. Korean J Lab Med. 28: 130-5. PMID: 18458509
8. Inhibition of methylation and changes in gene expression in relation to neural tube defects.  |  van der Linden, IJ., et al. 2008. Birth Defects Res A Clin Mol Teratol. 82: 676-83. PMID: 18937356
9. Identification of molecular heterogeneity in SNX27-retromer-mediated endosome-to-plasma-membrane recycling.  |  McGough, IJ., et al. 2014. J Cell Sci. 127: 4940-53. PMID: 25278552
10. Detecting Genetic Associations between ATG5 and Lupus Nephritis by trans-eQTL.  |  Zhang, YM., et al. 2015. J Immunol Res. 2015: 153132. PMID: 26509176
11. Retromer- and WASH-dependent sorting of nutrient transporters requires a multivalent interaction network with ANKRD50.  |  Kvainickas, A., et al. 2017. J Cell Sci. 130: 382-395. PMID: 27909246
12. Dissecting the genetic heterogeneity of gastric cancer.  |  Hess, T., et al. 2023. EBioMedicine. 92: 104616. PMID: 37209533

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ANKRD50 Antibody (E-12) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-ANKRD50 Antibody (E-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ANKRD50 Antibody (E-12) Specifications

Alternate Product Name: ANKRD50

Product Clone Name: E-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1303-1318

Epitope Target: ANKRD50

Epitope Species: human

Product Reactivity/Detection: ANKRD50

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for ANKRD50 Antibody (E-12): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin